Minimal prognostic significance of sentinel lymph node metastasis in patients with cT1-2 and cN0 breast cancer

World Journal of Surgical Oncology
Hideo ShigematsuShinji Ozaki

Abstract

The prognostic value of sentinel lymph node (SLN) metastases may be minimized by the limited disease burden of lymph node metastases and tailoring adjuvant therapy based on breast cancer biology. The aim of this study is to assess the prognostic significance of SLN metastasis in patients with cT1-2N0M0 breast cancer. Between January 2006 and December 2015, 582 patients underwent SLN biopsy for cT1-2N0M0 breast cancers. cN0 was essentially diagnosed by ultrasound sonography. The prognostic values of SLN metastases were retrospectively evaluated. Among 582 patients with cT1-2N0M0 breast cancer, 111 patients (19.1%) were positive for SLN metastasis, including 39 cases (6.7%) of micrometastasis and 72 cases (12.4%) of macrometastases. The median size of SLN metastasis was 3.0 mm (range 0.2-16 mm, mean 4.1 mm). In log-rank test, presence of SLN metastasis was not associated with breast cancer recurrence (p = 0.21); 5-year and 10-year recurrence-free survival (RFS) were 93.0% and 96.5%, and 93.0% and 90.4% in the SLN-positive and SLN-negative groups, respectively. In the propensity score matching cohort (n = 178), there was no significant difference in RFS between the SLN-positive and SLN-negative groups (p = 0.90). In Cox regression...Continue Reading

References

Sep 9, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yvette AnderssonLeif Bergkvist
Jan 21, 2011·The New England Journal of Medicine·Donald L WeaverNorman Wolmark
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Dec 10, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A MittendorfKelly K Hunt
Jan 8, 2015·The New England Journal of Medicine·Sara M TolaneyEric P Winer
Jul 28, 2015·Lancet·UNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Aug 25, 2016·The New England Journal of Medicine·Fatima CardosoUNKNOWN MINDACT Investigators
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jul 25, 2017·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rikiya NakamuraMasayuki Ohtsuka
Nov 3, 2017·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hideo ShigematsuKiyomi Taniyama
May 31, 2018·Breast Cancer Research and Treatment·Yvette AnderssonJ de Boniface

❮ Previous
Next ❯

Citations

Dec 19, 2020·European Journal of Radiology·Fabian RiedelJoerg Heil
Feb 6, 2020·Critical Reviews in Oncology/hematology·Angel MonteroCarmen Rubio
Mar 20, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinsuke SasadaMorihito Okada
May 2, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E P MamounasS Loibl
Jun 24, 2021·World Journal of Surgical Oncology·Zhu-Jun LohHui-Ping Hsu
Jul 10, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mahaveer S SanghaMuneer Ahmed

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
nucleic acid amplification
dissections
dissection

Software Mentioned

JMP

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

© 2022 Meta ULC. All rights reserved