PMID: 8603001Feb 1, 1996Paper

Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia: a metaphase-FISH study

British Journal of Haematology
W El-RifaiS Knuutila

Abstract

Metaphase-FISH was adopted for the detection of proliferating Philadelphia-positive (Ph+) residual leukaemic cells in 25 patients with chronic myeloid leukaemia treated with allogeneic bone marrow transplantation (BMT). Patients were followed up during their clinical remission for 4-50 months (median 17 months) after BMT. 80 bone marrow samples were studied. For most of the cases no fewer than 1000 metaphases were analysed. Six patients (24%) showed residual Ph+ cells during the first 6 months and two others by the end of the first year after BMT. Three patients relapsed during the study and in two of them residual Ph+ cells were detected during the first 6 months after BMT. In 17 patients no Ph+ cells were detected at any stage of follow-up and 16 (94.1%) of them continue in complete clinical and haematological remission. Our results indicate that metaphase-FISH is a reliable tool in the quantitation of proliferating residual leukaemic cells. We suggest that consecutive findings of equal amounts of residual leukaemic cells do not necessarily predict a relapse. However, their presence calls for follow-up at shorter intervals where an increasing number of these cells predicts an ensuing relapse.

Citations

Aug 5, 2003·Current Oncology Reports·Vivian G Oehler, Jerald P Radich
Aug 26, 1998·Critical Reviews in Oncology/hematology·S Faderl, Z Estrov
Apr 17, 1998·Journal of Pediatric Hematology/oncology·K VettenrantaU M Saarinen-Pihkala
Jun 1, 1997·Baillière's Clinical Haematology·S O'BrienM J Siciliano
Apr 28, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M SeongR E Champlin

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