PMID: 9450818Feb 5, 1998Paper

Minimal residual disease analysis for the prediction of relapse in children with standard-risk acute lymphoblastic leukaemia

British Journal of Haematology
N J GouldenA Oakhill

Abstract

We report a largely retrospective analysis of minimal residual disease (MRD) in a cohort of 66 children suffering from acute lymphoblastic leukaemia (ALL). All patients lacked high-risk features at diagnosis, i.e. the presenting white cell count was <50 x 10(9)/l, age 1-16 years and translocations t(9;22) and t(4;11) were not present. All were treated according to either the MRC protocols UKALL X or XI. PCR of IgH, TCRdelta and TCRgamma gene rearrangements and allele-specific oligoprobing were employed for the detection of MRD. Sensitivity was at least 10(-4) in 78/82 (93%) probes examined. A total of 33 patients relapsed (seven on therapy and 26 off) and 33 remain in continuing complete remission (CCR) (median follow-up 69 months from diagnosis). Of those who remain in CCR, MRD was present in the bone marrow in 32%, 10% and 0% at 1, 3 and 5 months into therapy respectively. This is in marked contrast to the presence of MRD at these times in 82%, 60% and 41% of patients who relapsed (P<0.001, P<0.005 and P<0.005). These results provide further evidence of a strong correlation between clearance of MRD early in therapy and clinical outcome in childhood ALL.

References

Oct 1, 1990·Baillière's Clinical Haematology·D CampanaG Janossy
May 18, 1989·Nature·S Kwok, R Higuchi
Jun 15, 1995·The New England Journal of Medicine·C H Pui
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P G SteinherzW A Bleyer
Jan 30, 1997·The New England Journal of Medicine·W M RobertsT F Zipf
Apr 1, 1995·Clinical Molecular Pathology·C J KnechtliM N Potter

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Citations

Mar 10, 2001·The Journal of Molecular Diagnostics : JMD·D A Arber
Aug 27, 1998·The New England Journal of Medicine·A Morley
Feb 25, 2000·Current Opinion in Oncology·C H Pui
Jul 10, 1999·Current Opinion in Hematology·J E Rubnitz, C H Pui
Nov 5, 1999·Current Opinion in Hematology·T Lion
Jul 6, 2000·Current Opinion in Hematology·E L Sievers, J P Radich
Feb 1, 2012·Seminars in Oncology·Monika BrüggemannMichael Kneba
Aug 16, 2005·British Journal of Haematology·Louise K Jones, Vaskar Saha
Jun 26, 2003·British Journal of Haematology·Peter J Campbell, Alexander A Morley
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze
May 4, 2002·Best Practice & Research. Clinical Haematology·Tomasz SzczepańskiJacques J M van Dongen
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Glenn M MarshallMurray D Norris
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Forida Y MortuzaLetizia Foroni
Nov 28, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·C A ScrideliL G Tone

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