Minimal residual disease and normalization of the bone marrow after long-term treatment with alpha-interferon2b in polycythemia vera. A report on molecular response patterns in seven patients in sustained complete hematological remission

Hematology
Thomas Stauffer LarsenHans Carl Hasselbalch

Abstract

Polycythemia vera (PV) is characterized by the presence of the JAK2V617F mutation in virtually all patients. Several studies have shown that the JAK2V617F mutational load decreases during treatment with alpha-interferon 2. We report on molecular and histomorphological bone marrow responses in seven PV patients with profound molecular responses during and after long-term treatment with alpha-interferon 2b. All patients obtained a major molecular response (MMR). Subsequently all patients discontinued alpha-interferon and sustained complete hematological remission with a follow-up period of median 10 months (range 4-30 months). Complete normalization of the bone marrow was seen in three of five patients. Long term treatment with IFN2b is able to induce 'minimal residual disease' with very low JAK2 V617F allele burden and may induce profound, and in some patients total, regression of histomorphological bone marrow features of PV. Finally, hematological remissions and major molecular responses can be sustained after discontinuation of long-term treatment with IFN2b.

References

Jul 13, 2007·Leukemia·A M VannucchiUNKNOWN MPD Research Consortium
Aug 23, 2007·Blood·Giovanni BarosiUNKNOWN Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Italian Registry of Myelofibrosis
Oct 27, 2007·European Journal of Haematology·Thomas Stauffer LarsenHans Carl Hasselbalch

❮ Previous
Next ❯

Citations

Feb 5, 2013·Expert Review of Hematology·Richard T SilverHans Carl Hasselbalch
Feb 19, 2013·Cytokine & Growth Factor Reviews·Hans C Hasselbalch
Dec 25, 2015·The New England Journal of Medicine·Gabriela M BaerlocherDavid S Snyder
Nov 6, 2015·Mediators of Inflammation·Mads Emil Bjørn, Hans Carl Hasselbalch
Dec 7, 2013·Clinical Lymphoma, Myeloma & Leukemia·Richard T Silver
Nov 26, 2015·Mediators of Inflammation·Hans Carl Hasselbalch, Mads Emil Bjørn
Jul 30, 2016·European Journal of Haematology·Iben Onsberg HansenHans Carl Hasselbalch
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans Carl HasselbalchRichard T Silver
Feb 6, 2017·Blood·Adam J Mead, Ann Mullally
Nov 28, 2018·British Journal of Haematology·Mary Frances McMullinUNKNOWN BSH Committee
May 23, 2015·Expert Review of Hematology·Hans Carl Hasselbalch, Richard T Silver
Mar 11, 2011·Blood·Jean-Jacques KiladjianRonald Hoffman
May 6, 2020·Expert Opinion on Therapeutic Targets·Niccolò BartalucciAlessandro M Vannucchi
Feb 1, 2019·Terapevticheskiĭ arkhiv·A L MelikyanV G Savchenko
Oct 30, 2014·Expert Review of Hematology·Srdan Verstovsek, Rami S Komrokji
Dec 25, 2015·The New England Journal of Medicine·Mads E BjørnHans C Hasselbalch
Aug 12, 2017·Expert Review of Hematology·Lucia MasarovaNaval Daver
Jun 23, 2019·Current Hematologic Malignancy Reports·Lucia MasarovaSrdan Verstovsek
Dec 29, 2015·The New England Journal of Medicine·Ayalew Tefferi
Sep 28, 2017·Current Hematologic Malignancy Reports·Charles Elliott Foucar, Brady Lee Stein
Mar 25, 2021·Therapeutics and Clinical Risk Management·Giulia BenevoloValentina Giai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.