Minimal residual disease in hypopigmented mycosis fungoides

Journal of the American Academy of Dermatology
Pa-Fan HsiaoShiou-Hwa Jee

Abstract

We describe the case of a 13-year-old boy with stage I hypopigmented mycosis fungoides in whom minimal residual disease was detected with T-cell receptor gamma-polymerase chain reaction after the disease was in complete clinical remission. We further cloned and sequenced the T-cell receptor gamma-polymerase chain reaction product of the lesion in remission and found that the original T-cell clone still existed in decreased amounts. The patient was followed up for 3 1/2 years without any new lesions developing. The clinical significance of this residual malignant T-cell clone in mycosis fungoides remains to be elucidated.

References

Sep 7, 2000·Ceskoslovenská patologie·F FakanS Námĕstek
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C ThériaultT Al Saati
Feb 18, 2003·The British Journal of Dermatology·E Poszepczynska-GuigneM-H Delfau-Larue
Aug 20, 2003·The Journal of Investigative Dermatology·Olivier DereureJean-François Eliaou

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Citations

Jan 30, 2014·Anais Brasileiros De Dermatologia·Fabricio Cecanho Furlan, José Antonio Sanches
Nov 24, 2012·Seminars in Cutaneous Medicine and Surgery·Janyana M D Deonizio, Joan Guitart
Nov 7, 2020·The American Journal of Dermatopathology·Jin Cheol Kim, You Chan Kim

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