Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.

Current Environmental Health Reports
Lauren M PetrickMegan M Niedzwiecki

Abstract

The advent of low-volume biosampling and novel biomarker matrices offers non- or minimally invasive approaches to sampling in children. These new technologies, combined with advancements in mass spectrometry that provide high sensitivity, robust measurements of low-concentration exposures, facilitate the application of untargeted metabolomics in children's exposome research. Here, we review emerging sampling technologies for alternative biomatrices-dried capillary blood, interstitial fluid, saliva, teeth, and hair-and highlight recent applications of these samplers to drive discovery in population-based exposure research. Biosampling and biomarker technologies demonstrate potential to directly measure exposures during key developmental time periods. While saliva is the most traditional of the reported biomatrices, each technology has key advantages and disadvantages. For example, hair and teeth provide retrospective analysis of past exposures, and dried capillary blood provides quantitative measurements of systemic exposures that can be more readily compared with traditional venous blood measurements. Importantly, all technologies can or have the potential to be used at home, increasing the convenience and parental support for ...Continue Reading

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Citations

Apr 15, 2021·Acta Paediatrica·Aline U BjerkhaugClaus Klingenberg

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Methods Mentioned

BETA
blood collection
chip
blood draws
nuclear magnetic resonance
NMR

Software Mentioned

VAMS

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