Minimally invasive pancreatoduodenectomy is associated with lower morbidity compared to open pancreatoduodenectomy: An updated meta-analysis of randomized controlled trials and high-quality nonrandomized studies

Medicine
Jia-Fei YanQi-Long Chen

Abstract

Minimally invasive pancreatoduodenectomy (MIPD) is being increasingly performed as an alternative to open pancreatoduodenectomy (OPD) in selected patients. Our study aimed to present a meta-analysis of the high-quality studies conducted that compared MIPD to OPD performed for pancreatic head and periampullary diseases. A systematic review of the available literature was performed to identify those studies conducted that compared MIPD to OPD. Here, all randomized controlled trials identified were included, while the selection of high-quality, nonrandomized comparative studies were based on a validated tool (i.e., Methodological Index for Nonrandomized Studies). Intraoperative outcomes, postoperative recovery, oncologic clearance, and postoperative complications were also evaluated. Sixteen studies matched the selection criteria, including a total of 3168 patients (32.1% MIPD, 67.9% OPD). The pooled data showed that MIPD was associated with a longer operative time (weighted mean difference [WMD] = 80.89 minutes, 95% confidence interval [CI]: 39.74-122.05, P < .01), less blood loss (WMD = -227.62 mL, 95% CI: -305.48 to -149.75, P < .01), shorter hospital stay (WMD = -4.68 days, 95% CI: -5.52 to -3.84, P < .01), and an increase in ...Continue Reading

References

Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Jul 9, 2005·Surgery·Claudio BassiUNKNOWN International Study Group on Pancreatic Fistula Definition
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N Volkan AdsayCharles Staley
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Mar 18, 2011·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Ning-xin ZhouXiong-fei Chen
May 4, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Amer H ZureikatSteven J Hughes
Sep 29, 2011·World Journal of Surgery·Nicolas Christian BuchsPier Cristoforo Giulianotti
May 4, 2012·The New England Journal of Medicine·Atul Gawande
Jun 27, 2012·International Journal of Surgery·Eric C H LaiChung Ngai Tang
Jul 5, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter J KneuertzTimothy M Pawlik
Sep 25, 2012·Journal of the American College of Surgeons·Horacio J Asbun, John A Stauffer
Nov 6, 2012·Journal of the American College of Surgeons·Mark P CalleryCharles M Vollmer
Jun 8, 2013·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Zhao LeiZhai Bo
Nov 16, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Philip Q BaoKevin T Watkins
Nov 28, 2013·Journal of the American College of Surgeons·Camilo Correa-GallegoPeter J Allen
Jun 14, 2014·Annals of Surgical Oncology·Paul J SpeicherAlexander Perez
Aug 1, 2014·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Yifan WangTsafrir Vanounou
Aug 8, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Abdul R HakeemKrishna V Menon
Oct 3, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kris P CroomeMichael L Kendrick
Apr 5, 2015·Journal of the American College of Surgeons·Safi DokmakAlain Sauvanet
May 9, 2015·World Journal of Gastroenterology : WJG·Chun-Lu TanKe-Zhou Li
Jul 24, 2015·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·E H BakerJ B Martinie
Aug 22, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·May C TeeMichael L Kendrick
Sep 17, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Shuyin Liang, Shiva Jayaraman
Mar 26, 2016·Surgical Oncology Clinics of North America·Deepa MaggeHerbert J Zeh
May 5, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel DelittoSteven J Hughes
May 22, 2016·World Journal of Surgery·Ugo BoggiGabriella Amorese

❮ Previous
Next ❯

Citations

Aug 29, 2020·Surgery Today·Yoshihiro MiyasakaMasafumi Nakamura
Oct 28, 2020·The Journal of International Medical Research·Kate NongXuemin Chen
Mar 30, 2020·Cancer Research·Christopher GromischMark W Grinstaff
Apr 10, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ruth HimmelsbachDietrich A Ruess

❮ Previous
Next ❯

Software Mentioned

Methodological Index for Nonrandomized Studies ( MINORS )
Embase
RevMan
Google Scholar

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.