Minimally Invasive Surgery Combined with Regenerative Biomaterials in Treating Intra-Bony Defects: A Meta-Analysis

PloS One
Shan LiuJinlin Song

Abstract

With the popularity of minimally invasive surgery (MIS) in periodontics, numerous publications have evaluated the benefits of MIS with or without various regenerative biomaterials in the treatment of periodontal intra-bony defects. However, it is unclear if it is necessary to use biomaterials in MIS. Thus, we conducted a meta-analysis of randomized clinical trials in patients with intra-bony defects to compare the clinical outcomes of MIS with regenerative biomaterials for MIS alone. The authors retrieved English publications on relevant studies from Cochrane CENTRAL, PubMed, Medline, Embase, Clinical Evidence, and ClinicalTrials.gov (up to June 30, 2015). The main clinical outcomes were the reduction of probing pocket depths (PPDs), gain of clinical attachment level (CAL), recession of gingival margin (REC) and radiographic bone fill. Review Manager 5.2 (Cochrane Collaboration, Oxford, England) was used to calculate the heterogeneity and mean differences of the main clinical outcomes. In total, 464 studies in the literature were identified but only four were ultimately feasible. The results showed no significant difference regarding CAL gain (P = 0.32) and PPD reduction (P = 0.40) as well as REC increase (P = 0.81) and radiogr...Continue Reading

References

Sep 1, 1987·Journal of Clinical Periodontology·S P RamfjordD L Stults
Sep 1, 1985·Journal of Clinical Periodontology·F IsidorT Karring
Jan 1, 1971·Scandinavian Journal of Dental Research·P Holm-Pedersen, H Löe
Feb 1, 1996·Journal of Periodontology·W B KaldahlJ K Dyer
Mar 30, 2001·Periodontology 2000·N P Lang
Apr 23, 2002·Journal of Clinical Periodontology·Maurizio S TonettiBeat Wallkamm
Jun 6, 2003·Journal of Clinical Periodontology·Leonardo TrombelliAlessandro Scabbia
Apr 29, 2005·Journal of Periodontology·Stephen K HarrelMartha E Nunn
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Nov 10, 2006·Journal of Clinical Periodontology·Ivan BokanUlrich Schlagenhauf
Oct 24, 2007·Journal of Clinical Periodontology·Pierpaolo Cortellini, Maurizio S Tonetti
Sep 9, 2008·Journal of Clinical Periodontology·Leonardo Trombelli, Roberto Farina
Feb 4, 2009·Journal of Periodontology·Leonardo TrombelliGiorgio Calura
May 19, 2010·Journal of Periodontology·Michael P Rethman, Stephen K Harrel
May 23, 2012·Journal of Periodontology·Ivan B Darby, Kevin H Morris
Oct 17, 2012·The Journal of Evidence-based Dental Practice·Pierpaolo Cortellini

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