Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

Journal of Biomedical Optics
Sripriya RamamoorthyAlfred L Nuttall

Abstract

Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area to investigate cochlear processing of signals without significant intrusion. A simple method is developed to provide optical access to the guinea pig cochlear apex in two directions with minimal surgery. Furthermore, all prior vibration measurements in the guinea pig apex involved opening an observation hole in the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here, this limitation is overcome by measuring the vibrations through the unopened otic capsule using phase-sensitive Fourier domain optical coherence tomography. The optically and surgically advanced method described here lays the foundation to perform minimally invasive investigation of speech-related signal processing in the cochlea.

References

Feb 1, 1991·Hearing Research·A L NuttallG Avinash
Apr 1, 1971·The Journal of the Acoustical Society of America·W S Rhode
Dec 1, 1980·The Journal of the Acoustical Society of America·J B Allen
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·A W GummerH P Zenner
Apr 1, 1996·The Journal of the Acoustical Society of America·R Nobili, F Mammano
Mar 1, 1996·The Journal of the Acoustical Society of America·A L Nuttall, D F Dolan
Jun 7, 2007·The Journal of the Acoustical Society of America·Sripriya RamamoorthyKarl Grosh
Sep 15, 2012·Hearing Research·Alfred L Nuttall, Anders Fridberger
Feb 12, 2014·Journal of the Association for Research in Otolaryngology : JARO·J T LichtenhanA N Salt

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Citations

Jul 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rebecca L WarrenAnders Fridberger
Apr 7, 2017·The Journal of Physiology·Alberto Recio-Spinoso, John S Oghalai
Oct 12, 2018·Nature Communications·Alfred L NuttallAnders Fridberger
Jan 23, 2020·Communications Biology·Tianying Ren, Wenxuan He

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