Minimally invasive therapy of cervical intraepithelial neoplasia for fertility preservation.

Pathology Oncology Research : POR
Darko MilinovicSlavko Oreskovic

Abstract

The aim of this study was to determine the extension of cervical intraepithelial neoplasia grade III (CIN III) into endocervical canal and depth of endocervical crypts involvement by CIN with the regard to patients' age and parity. Correlation between the area of CIN involvement and the extension into endocervical canal was estimated. A total of 218 cervical cone specimens with histologically proven CIN III were included in this study. Extension of CIN into the endocervical canal, depth of involved crypts and ectocervical area affected by CIN were histologically analyzed. The average endocervical crypt involvement was at 1.2 mm of depth. The excision of >4 mm (1.2 mm x 3S.D.) in depth removes >99% of CIN. With the cone length of 15 mm (nulliparous patients) and 18 mm (multiparous patients), no endocervical cone margins were affected with CIN. Since the cone length is the most important determining factor for fertility preservation, the measurement of cervical cone could be essential for future pregnancies.

References

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Citations

Sep 6, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lúcia Maria KliemannRicardo Dos Reis
May 20, 2011·Australian Dental Journal·I Darby
Aug 29, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Burak GiraySerkan Akis
Jul 21, 2017·Gynecologic Oncology Research and Practice·Brett MilesBradley J Monk

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