Minimising the effects of bolus dispersion in bolus-tracking MRI

NMR in Biomedicine
Lisa WillatsFernando Calamante

Abstract

Bolus-tracking perfusion measurements in patients with vascular abnormalities are often unreliable, because delay and/or dispersion of the bolus within the vessels distorts the measured arterial input function (AIF). Erroneous measurements of perfusion can be identified by examining the measured response function, the shape of which is determined by both the tissue and arterial retention. In this work, an accurate response function is extracted by combining maximum-likelihood expectation-maximisation deconvolution, regularised using an oscillation index, with subsequent wavelet thresholding. Simulations show that this method recovers both the smooth-dispersed and the sharp-delayed response functions. This enables regions where the bolus is delayed and/or dispersed to be identified when the methodology is applied to data from patients with vascular abnormalities. Simulations also demonstrate robust and accurate perfusion estimates when there is no bolus delay and/or dispersion. The presence of delay and/or dispersion in the response function suggests that the perfusion measurements are erroneous, and that the global AIF is an inaccurate approximation to the true AIF in these regions. Perfusion measurements are corrected within t...Continue Reading

References

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Jun 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lisa WillatsFernando Calamante

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Citations

May 27, 2011·Topics in Magnetic Resonance Imaging : TMRI·Fernando Calamante
Sep 10, 2011·International Journal of Biomedical Imaging·Andreas FieselmannRebecca Fahrig
Jun 2, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lisa WillatsFernando Calamante
Dec 24, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoji TanakaTimothy Q Duong
Apr 16, 2009·Contrast Media & Molecular Imaging
Jan 21, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amit MehndirattaMichael A Chappell
Sep 21, 2010·NeuroImage·Kenneth K KwongDavid A Chesler
Feb 5, 2014·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kohsuke KudoMakoto Sasaki
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Fernando Calamante
Sep 24, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Geon-Ho JahngFernando Calamante
Nov 1, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Midas MeijsFernando Calamante
Mar 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xingfeng ShaoLirong Yan

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