Minimising the population risk of micronutrient deficiency and over-consumption: a new approach using selenium as an example

European Journal of Nutrition
A G RenwickT Wildemann

Abstract

At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole population. These values provide only limited guidance to risk managers. A method has been developed recently which models the relationships between intake and risks of either deficiency or excess using an observed incidence for each effect and population distribution characteristics. Using this model it is possible to formulate advice to risk managers on the incidence (prevalence) of adverse effects, due to either deficiency or excess, at different levels of intake. Application of the model to the data used to derive the RDA and UL for selenium shows that it can predict the impact of changes in nutrient intake on the balance between benefit (absence of deficiency) and risk (development of toxicity). Application of the model has illustrated the utility of this approach, but highlighted the need for a comprehensive evaluation of the data and a critical appraisal of the validity of the relationships that are analyzed. In addition, th...Continue Reading

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Citations

Sep 24, 2010·The Proceedings of the Nutrition Society·Susan J Fairweather-TaitRachel Collings
Sep 4, 2010·Antioxidants & Redox Signaling·Susan J Fairweather-TaitRachel Hurst
Feb 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L NasreddineN Hwalla
Jul 1, 2008·Toxicology Letters·A G Renwick, R Walker
Apr 9, 2015·Frontiers in Plant Science·Zhilin WuMiao Li
Jan 27, 2017·Frontiers in Plant Science·Meetu Gupta, Shikha Gupta
Feb 9, 2017·Journal of Environmental Quality·Michela Schiavon, Elizabeth A H Pilon-Smits

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