Minimizing AED adverse effects: improving quality of life in the interictal state in epilepsy care.

Current Neuropharmacology
Erik K St Louis

Abstract

The goals of epilepsy therapy are to achieve seizure freedom while minimizing adverse effects of treatment. However, producing seizure-freedom is often overemphasized, at the expense of inducing adverse effects of treatment. All antiepileptic drugs (AEDs) have the potential to cause dose-related, "neurotoxic" adverse effects (i.e., drowsiness, fatigue, dizziness, blurry vision, and incoordination). Such adverse effects are common, especially when initiating AED therapy and with polytherapy. Dose-related adverse effects may be obviated in most patients by dose reduction of monotherapy, reduction or elimination of polytherapy, or substituting for a better tolerated AED. Additionally, all older and several newer AEDs have idiosyncratic adverse effects which usually require withdrawal in an affected patient, including serious rash (i.e., Stevens-Johnson Syndrome, toxic epidermal necrolysis), hematologic dyscrasias, hepatotoxicity, teratogenesis in women of child bearing potential, bone density loss, neuropathy, and severe gingival hyperplasia. Unfortunately, occurrence of idiosyncratic AED adverse effects cannot be predicted or, in most cases, prevented in susceptible patients. This article reviews a practical approach for the defi...Continue Reading

Citations

Aug 24, 2010·Current Treatment Options in Neurology·John D Hixson
Jun 5, 2012·Current Treatment Options in Neurology·Paul W Shepard, Erik K St Louis
Apr 13, 2011·Epilepsy Research·Lizbeth Hernandez-RonquilloJose F Tellez-Zenteno
Jul 23, 2013·Journal of Hepatology·Tsukasa KawaguchiTetsuo Takehara
Apr 9, 2016·Drugs·Matt Shirley, Sohita Dhillon
Apr 8, 2015·Anesthesia Progress·Shigeru MaedaTakuya Miyawaki
Sep 21, 2013·European Journal of Pharmacology·Antonio SiniscalchiGiovambattista De Sarro
Dec 17, 2014·Epilepsy & Behavior : E&B·B ChenK Detyniecki
Apr 20, 2017·Journal of Child Neurology·Betül KılıçSezai Yılmaz
May 22, 2019·Advances in Nutrition·Jae Young KwonSang Ryong Kim
Jul 17, 2019·Current Pharmaceutical Design·Hira ChoudhuryBapi Gorain
Nov 21, 2019·Acta Neurologica Scandinavica·Ji Hyun KimSang Ahm Lee
Nov 1, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhongliang DuLianting Shi
Feb 12, 2020·Acta neurologica Belgica·Aslı Ece Çilliler, Bülent Güven
Mar 27, 2018·Neuro-oncology·Fadi S SaadehMark D Krieger
Nov 29, 2020·Epilepsy & Behavior : E&B·Benzi M KlugerMark Spitz
Feb 24, 2021·Drugs & Aging·Marian GalovicMatthias J Koepp
Jun 8, 2021·JAMA Neurology·Kimford J MeadorUNKNOWN Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Investigator Group
Jul 24, 2021·Otolaryngologic Clinics of North America·Richard BaronJennifer Alyono
Aug 17, 2021·Journal of Epilepsy Research·Jun-Sang SunwooDae-Won Seo
Apr 5, 2020·Epilepsy & Behavior : E&B·Adriana Reyes-MirandaMary Jo Pugh

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