Minimizing Interpolation Bias and Precision Error in In Vivo µCT-Based Measurements of Bone Structure and Dynamics

Annals of Biomedical Engineering
Chantal M J de BakkerX Sherry Liu

Abstract

In vivo µCT imaging allows for high-resolution, longitudinal evaluation of bone properties. Based on this technology, several recent studies have developed in vivo dynamic bone histomorphometry techniques that utilize registered µCT images to identify regions of bone formation and resorption, allowing for longitudinal assessment of bone remodeling. However, this analysis requires a direct voxel-by-voxel subtraction between image pairs, necessitating rotation of the images into the same coordinate system, which introduces interpolation errors. We developed a novel image transformation scheme, matched-angle transformation (MAT), whereby the interpolation errors are minimized by equally rotating both the follow-up and baseline images instead of the standard of rotating one image while the other remains fixed. This new method greatly reduced interpolation biases caused by the standard transformation. Additionally, our study evaluated the reproducibility and precision of bone remodeling measurements made via in vivo dynamic bone histomorphometry. Although bone remodeling measurements showed moderate baseline noise, precision was adequate to measure physiologically relevant changes in bone remodeling, and measurements had relatively ...Continue Reading

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Citations

Jan 22, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chantal Mj de BakkerX Sherry Liu
May 4, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Allison R Altman-SinglesX Sherry Liu
Jul 25, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chantal Mj de BakkerX Sherry Liu
Nov 17, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J DuV V Silberschmidt
Jul 28, 2021·International Journal for Numerical Methods in Biomedical Engineering·Tannis D KempSteven K Boyd

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