Minimizing right ventricular pacing in pacemaker patients with intact and compromised atrioventricular conduction : Results from the EVITA Trial

Herzschrittmachertherapie & Elektrophysiologie
A BauerP Peytchev

Abstract

Unnecessary ventricular pacing is associated with increased morbidity and mortality. Over the years different algorithms have been developed to reduce right ventricular pacing. Goal of the present study was to test the efficacy of the ventricular intrinsic preference (VIP) algorithm in patients with atrioventricular intact (AVi) and atrioventricular compromised (AVc) AV-conduction. Evaluation of VIP feature in pacemaker patients (EVITA) was a multicenter, prospective, randomized trial (Trials.gov Identifier: NCT00366158). In total, 389 patients were randomized to AVc group: n = 140/132 VIP OFF/VIP On, AVi group: n = 54/63 VIP OFF/VIP ON). One-month post-implantation AV conduction testing (AVc: PR/AR interval > 210 ms) was performed. Follow-up visits occurred 6 and 12 months after DDD-pacemaker implantation. In AVi and AVc-patients initiation of the VIP feature significantly reduced incidence of ventricular pacing (AVi: 53 ± 38 vs. 9 ± 21%, p = 0.0001; AVc: 79 ± 31 vs. 28 ± 35%, p = 0.0001). DDD-pacemaker implantation per se significantly reduced incidence of AF in VIP ON (AVi 27 vs. 0%, p < 0.0001; AVc 29 vs. 3%, p < 0.0001) and VIP OFF patients (AVi 43 vs. 4%, p < 0.0001; AVc 33 vs. 3, p < 0.0001), without significant differen...Continue Reading

Associated Clinical Trials

References

Nov 1, 1992·Pacing and Clinical Electrophysiology : PACE·T IshikawaM Ishii
May 30, 1998·Pacing and Clinical Electrophysiology : PACE·U StierleJ Potratz
Jun 14, 2002·The New England Journal of Medicine·Gervasio A LamasUNKNOWN Mode Selection Trial in Sinus-Node Dysfunction
Jan 3, 2003·JAMA : the Journal of the American Medical Association·Bruce L WilkoffUNKNOWN Dual Chamber and VVI Implantable Defibrillator Trial Investigators
Aug 17, 2005·Journal of Cardiovascular Electrophysiology·Michael O SweeneyUNKNOWN Marquis MVP Download Investigators
May 3, 2006·Pacing and Clinical Electrophysiology : PACE·Goran MilasinovicUNKNOWN Worldwide EnPulse Investigators
Aug 4, 2006·Pacing and Clinical Electrophysiology : PACE·Anne M GillisUNKNOWN Medtronic Enrhythm Clinical Study Investigators
Sep 7, 2007·The New England Journal of Medicine·Michael O SweeneyUNKNOWN Search AV Extension and Managed Ventricular Pacing for Promoting Atrioventricular Conduction (SAVE PACe) Trial
Jan 22, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Goran MilasinovicJohannes Sperzel
Feb 1, 2008·Pacing and Clinical Electrophysiology : PACE·Helmut PürerfellnerGoran Milasinovic
Mar 11, 2009·Pacing and Clinical Electrophysiology : PACE·Bernard ThibaultRemi Nitzsche
Mar 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R GoldUNKNOWN SAFARI Investigators
Aug 12, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·John SilberbauerNeil Sulke
Sep 19, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yoshimasa MurakamiMitsuaki Takami
Jan 7, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Rick A VeaseyA Neil Sulke
Feb 9, 2011·European Heart Journal·Jens Cosedis NielsenUNKNOWN DANPACE Investigators
Mar 26, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Carsten W Israel
Mar 29, 2011·Pacing and Clinical Electrophysiology : PACE·Christof KolbUNKNOWN PREVENT study group

❮ Previous
Next ❯

Citations

Sep 18, 2016·Circulation. Arrhythmia and Electrophysiology·Angelo Auricchio, Kenneth A Ellenbogen
Sep 29, 2018·Pacing and Clinical Electrophysiology : PACE·Christopher MonkhouseJonathan M Behar
Jan 15, 2021·Journal of Medical Case Reports·Fu GuanRui Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.