Minimizing tip-sample forces in jumping mode atomic force microscopy in liquid

Ultramicroscopy
A Ortega-EstebanJulio Gomez-Herrero

Abstract

Control and minimization of tip-sample interaction forces are imperative tasks to maximize the performance of atomic force microscopy. In particular, when imaging soft biological matter in liquids, the cantilever dragging force prevents identification of the tip-sample mechanical contact, resulting in deleterious interaction with the specimen. In this work we present an improved jumping mode procedure that allows detecting the tip-sample contact with high accuracy, thus minimizing the scanning forces (-100 pN) during the approach cycles. To illustrate this method we report images of human adenovirus and T7 bacteriophage particles which are prone to uncontrolled modifications when using conventional jumping mode.

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Citations

Aug 1, 2014·Micron : the International Research and Review Journal for Microscopy·J V Méndez-MéndezR D Snook
Jul 30, 2014·Nature Communications·M Hernando-PérezP J de Pablo
Oct 23, 2015·ACS Nano·Alvaro Ortega-EstebanPedro J de Pablo
Mar 15, 2013·Scientific Reports·A Ortega-EstebanP J de Pablo
Aug 1, 2015·Nanoscale·M Hernando-PérezP J de Pablo
Feb 11, 2014·Biophysical Journal·Aida LlauróPedro J de Pablo
Jul 23, 2015·Biophysical Journal·Aida LlauróPedro J de Pablo
Feb 16, 2016·Nanoscale·Pablo AresFernando Moreno-Herrero
Jul 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Milagros CastellanosMauricio G Mateu
Aug 25, 2016·ACS Nano·Aida LlauróTrevor Douglas
Apr 15, 2018·Journal of Biological Physics·Pedro J de PabloJosé L Carrascosa
Apr 15, 2017·Biochemical Society Transactions·Francisco Moreno-MadridPedro J de Pablo
Dec 28, 2012·Journal of Virology·Joost SnijderGijs J L Wuite
Oct 3, 2018·International Journal of Molecular Sciences·Adrian P NievergeltGeorg E Fantner
Jan 20, 2018·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Natalia Martín-GonzálezPedro J de Pablo
May 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mercedes Hernando-PérezCarmen San Martín
Jul 14, 2012·The Journal of Biological Chemistry·Ana J Pérez-BernáCarmen San Martín
Aug 28, 2020·Frontiers in Molecular Biosciences·Daan VorselenGijs J L Wuite
Feb 18, 2016·The Journal of Biological Chemistry·Dragomir MilovanovicGeert van den Bogaart
Jul 30, 2020·Scientific Reports·Udom Sae-UengPenchit Chitnumsub
Jan 5, 2021·Frontiers in Molecular Biosciences·Natalia Martín-GonzálezPedro J De Pablo
Aug 19, 2021·Acta Biomaterialia·Marta Pérez-IllanaPedro J de Pablo

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