Minimum Clinically Important Difference of Gross Motor Function and Gait Endurance in Children with Motor Impairment: A Comparison of Distribution-Based Approaches.

BioMed Research International
Fabio Alexander StormEmilia Biffi

Abstract

The minimum clinically important difference (MCID) is a standard way of measuring clinical relevance. The objective of this work was to establish the MCID for the 6-minute walking test (6minWT) and the Gross Motor Function Measure (GMFM-88) in pediatric gait disorders. A cohort, pretest-posttest study was conducted in a hospitalized care setting. A total of 182 patients with acquired brain injury (ABI) or cerebral palsy (CP) performed 20 robot-assisted gait training sessions complemented with 20 sessions of physical therapy over 4 weeks. Separate MCIDs were calculated using 5 distribution-based approaches, complemented with an anonymized survey completed by clinical professionals. The MCID range for the 6minWT was 20-38 m in the ABI cohort, with subgroup ranges of 20-36 m for GMFCS I-II, 23-46 m for GMFCS III, and 24-46 m for GMFCS IV. MCIDs for the CP population were 6-23 m, with subgroup ranges of 4-28 m for GMFCS I-II, 9-19 m for GMFCS III, and 10-27 m for GMFCS IV. For GMFM-88 total score, MCID values were 1.1%-5.3% for the ABI cohort and 0.1%-3.0% for the CP population. For dimension "D" of the GMFM, MCID ranges were 2.3%-6.5% and 0.8%-5.2% for ABI and CP populations, respectively. For dimension "E," MCID ranges were 2.8%-...Continue Reading

References

Dec 1, 1989·Controlled Clinical Trials·R JaeschkeG H Guyatt
Apr 1, 1997·Developmental Medicine and Child Neurology·R PalisanoB Galuppi
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D OsobaJ Pater
Apr 9, 2002·Mayo Clinic Proceedings·Gordon H GuyattUNKNOWN Clinical Significance Consensus Meeting Group
Apr 22, 2003·American Journal of Physical Medicine & Rehabilitation·Kurt A Mossberg
Jun 5, 2004·Archives of Physical Medicine and Rehabilitation·Douglas I KatzReva B Klein
Jan 13, 2006·Archives of Physical Medicine and Rehabilitation·Hui-Yi Wang, Yi Hsin Yang
Apr 24, 2007·The Spine Journal : Official Journal of the North American Spine Society·Anne G CopayThomas C Schuler
Oct 3, 2007·Pediatrics·Michaela Linder-LuchtUNKNOWN Gross Motor Function Measure-Traumatic Brain Injury Study Group
Mar 22, 2008·Developmental Medicine and Child Neurology·Patricia ThompsonF Virginia Wright
May 10, 2008·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Carol A MaherTim S Olds
May 15, 2009·Child: Care, Health and Development·M ChevignardA Laurent-Vannier
Jan 1, 2008·The Journal of Manual & Manipulative Therapy·Chad E Cook
Nov 17, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Florian HeinenGuy Molenaers
Jan 11, 2011·American Journal of Physical Medicine & Rehabilitation·Nicola SmaniaDaniele Munari
Jan 28, 2012·Physical Therapy·Kurt A Mossberg, Elizabeth Fortini
Jun 23, 2012·American Journal of Respiratory and Critical Care Medicine·Stephen C MathaiRobert A Wise
Aug 2, 2013·The Journal of Manual & Manipulative Therapy·Alexis WrightAlicia Emerson Kavchak
Jan 21, 2016·Brazilian Journal of Physical Therapy·Kênnea M AlmeidaMarisa C Mancini
Sep 7, 2016·Journal of Evaluation in Clinical Practice·Richard W Bohannon, Rebecca Crouch
Apr 25, 2017·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Elisabetta PeriChiara Gagliardi
Apr 27, 2017·Orphanet Journal of Rare Diseases·Rudolf SchroverKaustuv Bhattacharya
Jul 29, 2017·Archives of Physical Medicine and Rehabilitation·Igor CarvalhoLuiz Alberto Batista
Mar 8, 2018·Developmental Medicine and Child Neurology·Adam T C BoothMarjolein M van der Krogt
Apr 14, 2018·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Elena BerettaSandra Strazzer
Aug 22, 2018·Annals of Clinical and Translational Neurology·Craig M McDonaldUNKNOWN DEMAND V study group
Jan 19, 2020·Archives of Physical Medicine and Rehabilitation·James F Malec, Jessica M Ketchum

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03828110

Software Mentioned

REDCap
REDCap Medea

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.