Abstract
Infant rats were passively immunized to determine the protective capacity of pneumococcal anticapsular antibodies. Animal-passaged strains of Streptococcus pneumoniae serotypes 1, 4, 5, 6b, 7f, 9v, 14, 18c, 19f, and 23f were used as challenge inocula (1-1500 cfu) in a model of pulmonary infection that resulted in bacteremia, meningitis, and death. From untreated control animals, histologic sections of lung demonstrated infiltrative pneumonia and lung homogenate cultures grew S. pneumoniae at concentrations of 10(3)-10(8) cfu per gram of lung tissue. A type-specific anti-capsular antibody serum concentration of 0.1-1.15 microg/mL resulted in a statistically significant reduction in mortality compared with the reduction in untreated controls, except for serotype 14, which required 2.32 microg/mL for a significant reduction in mortality. The serum antibody level that provided 50% reduction in mortality ranged from 0.1-3.5 microg/mL for all serotypes.
Citations
Oct 12, 2000·Vaccine·A NurkkaH Käyhty
Jun 18, 2002·Clinical and Experimental Immunology·J YusteJ Casal
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susanna EspositoNicola Principi
Feb 15, 2001·The Pediatric Infectious Disease Journal·S A Plotkin
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·L De HennezelJ M Alonso
Oct 16, 2008·Clinical Microbiology Reviews·Damiana ChiavoliniSusanna Ricci
Apr 22, 2003·Infection and Immunity·Amir ZlotkinAvi Eldar
Jul 26, 2005·Infection and Immunity·Tamika BurnsLiise-Anne Pirofski
Nov 26, 2009·Vaccine·A BallochM L K Tang
Oct 13, 2006·Vaccine·Isabelle HenckaertsJan Poolman
Aug 17, 2005·Infectious Disease Clinics of North America·Philip Toltzis, Michael R Jacobs
Nov 13, 2001·Bone Marrow Transplantation·T NordøyA Kolstad
Mar 10, 2001·Clinical and Diagnostic Laboratory Immunology·M VäkeväinenH Käyhty
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Catherine M WernetteMoon H Nahm
May 4, 1999·Infection and Immunity·W R Usinger, A H Lucas
Jul 23, 1999·Infection and Immunity·Z ZhongL Pirofski
Jul 25, 2000·Microbial Pathogenesis·E SaelandI Jonsdottir
Apr 13, 2000·Pediatric Clinics of North America·L G Rubin
Aug 2, 2000·Pediatrics·G D Overturf