Minimum protective serum concentrations of pneumococcal anti-capsular antibodies in infant rats

The Journal of Infectious Diseases
A M StackR A Saladino

Abstract

Infant rats were passively immunized to determine the protective capacity of pneumococcal anticapsular antibodies. Animal-passaged strains of Streptococcus pneumoniae serotypes 1, 4, 5, 6b, 7f, 9v, 14, 18c, 19f, and 23f were used as challenge inocula (1-1500 cfu) in a model of pulmonary infection that resulted in bacteremia, meningitis, and death. From untreated control animals, histologic sections of lung demonstrated infiltrative pneumonia and lung homogenate cultures grew S. pneumoniae at concentrations of 10(3)-10(8) cfu per gram of lung tissue. A type-specific anti-capsular antibody serum concentration of 0.1-1.15 microg/mL resulted in a statistically significant reduction in mortality compared with the reduction in untreated controls, except for serotype 14, which required 2.32 microg/mL for a significant reduction in mortality. The serum antibody level that provided 50% reduction in mortality ranged from 0.1-3.5 microg/mL for all serotypes.

References

Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susanna EspositoNicola Principi
Feb 15, 2001·The Pediatric Infectious Disease Journal·S A Plotkin
Oct 16, 2008·Clinical Microbiology Reviews·Damiana ChiavoliniSusanna Ricci
Apr 22, 2003·Infection and Immunity·Amir ZlotkinAvi Eldar
Aug 17, 2005·Infectious Disease Clinics of North America·Philip Toltzis, Michael R Jacobs
Mar 10, 2001·Clinical and Diagnostic Laboratory Immunology·M VäkeväinenHelena Käyhty
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Catherine M WernetteMoon H Nahm

Related Concepts

Mycoplasma pneumoniae
Histology Procedure
Keratin 6B protein
Lung
Infectious Disease of Lung
Cessation of Life
Klebsiella pneumoniae
Infiltration
Challenge
Lung Diseases

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