Minimum spanning tree analysis of the human connectome

Human Brain Mapping
E van DellenC J Stam

Abstract

One of the challenges of brain network analysis is to directly compare network organization between subjects, irrespective of the number or strength of connections. In this study, we used minimum spanning tree (MST; a unique, acyclic subnetwork with a fixed number of connections) analysis to characterize the human brain network to create an empirical reference network. Such a reference network could be used as a null model of connections that form the backbone structure of the human brain. We analyzed the MST in three diffusion-weighted imaging datasets of healthy adults. The MST of the group mean connectivity matrix was used as the empirical null-model. The MST of individual subjects matched this reference MST for a mean 58%-88% of connections, depending on the analysis pipeline. Hub nodes in the MST matched with previously reported locations of hub regions, including the so-called rich club nodes (a subset of high-degree, highly interconnected nodes). Although most brain network studies have focused primarily on cortical connections, cortical-subcortical connections were consistently present in the MST across subjects. Brain network efficiency was higher when these connections were included in the analysis, suggesting that th...Continue Reading

References

Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lin-Ching ChangCarlo Pierpaoli
May 23, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·UnCheol LeeKi-Young Jung
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Huijuan WangPiet Van Mieghem
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Nov 10, 2010·PloS One·Bernadette C M van WijkAndreas Daffertshofer
Feb 1, 2011·Methods in Molecular Biology·Derek K Jones, Alexander Leemans
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Apr 14, 2012·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martijn P van den HeuvelOlaf Sporns
Jan 9, 2013·NeuroImage·Marcel A de Reus, Martijn P van den Heuvel
Apr 2, 2013·Neurobiology of Aging·Betty M TijmsFrederik Barkhof
May 7, 2013·NeuroImage·Alex FornitoMichael Breakspear
Jan 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Joaquín GoñiOlaf Sporns
Apr 15, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C J StamP Van Mieghem
Jul 25, 2014·Brain : a Journal of Neurology·Nicolas A CrossleyEdward T Bullmore
Sep 5, 2014·Nature Reviews. Neuroscience·Cornelis J Stam
Feb 14, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C J StamP Van Mieghem
Mar 3, 2015·Chaos·Meichen YuCornelis Jan Stam
Dec 9, 2015·Schizophrenia Bulletin·Edwin van DellenIris E Sommer
Jul 2, 2016·NeuroImage·Andrew ZaleskyMichael Breakspear
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Peter T Bell, James M Shine
Sep 27, 2016·NeuroImage·James A RobertsMichael Breakspear

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Citations

Dec 21, 2018·Human Brain Mapping·Liqun KuangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 28, 2020·Brain Connectivity·Bruno M de Brito RobaloUNKNOWN Utrecht VCI Study Group
May 29, 2020·Translational Neurodegeneration·Haifeng ChenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 23, 2019·Network Neuroscience·Linda DouwCornelis J Stam
Dec 10, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Ilse M NautaMenno M Schoonheim
Jul 5, 2019·NeuroImage·Wei HeArjan Hillebrand

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS Statistics
FreeSurfer
FMRIB Software Library ( FSL
BEDPOSTX
recon
all
Diffusion Toolkit
MRtrix
Matlab
FSL Diffusion Toolbox

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