Mining and visualizing high-order directional drug interaction effects using the FAERS database.

BMC Medical Informatics and Decision Making
Xiaohui YaoLi Shen

Abstract

Adverse drug events (ADEs) often occur as a result of drug-drug interactions (DDIs). The use of data mining for detecting effects of drug combinations on ADE has attracted growing attention and interest, however, most studies focused on analyzing pairwise DDIs. Recent efforts have been made to explore the directional relationships among high-dimensional drug combinations and have shown effectiveness on prediction of ADE risk. However, the existing approaches become inefficient from both computational and illustrative perspectives when considering more than three drugs. We proposed an efficient approach to estimate the directional effects of high-order DDIs through frequent itemset mining, and further developed a novel visualization method to organize and present the high-order directional DDI effects involving more than three drugs in an interactive, concise and comprehensive manner. We demonstrated its performance by mining the directional DDIs associated with myopathy using a publicly available FAERS dataset. Directional effects of DDIs involving up to seven drugs were reported. Our analysis confirmed previously reported myopathy associated DDIs including interactions between fusidic acid with simvastatin and atorvastatin. Fu...Continue Reading

References

Jan 1, 1985·Human Toxicology·P G BlainM D Rawlins
Oct 28, 1999·Allergy·D A Moneret-VautrinL Plantier
Nov 25, 2004·The Annals of Pharmacotherapy·Shu-Hwa HsiaoTa-Jen Wu
Mar 27, 2007·Pharmacotherapy·Holli NelsonDavid Thomsen
Jun 15, 2007·The Annals of Pharmacotherapy·Marco TuccoriMario Del Tacca
Apr 26, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·M Y WuY H Liao
May 18, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Rosa Maria Rodrigues Pereira, Jozélio Freire de Carvalho
Mar 17, 2012·Science Translational Medicine·Nicholas P TatonettiRuss B Altman
Jul 15, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ying LiCarol Friedman
Oct 21, 2015·Nucleic Acids Research·Michael KuhnPeer Bork
Feb 19, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Heather EngAmit S Kalgutkar
Jul 9, 2016·Hemodialysis International·Min Seok ChoiDong Chan Jin
Aug 26, 2016·Journal of Medical Case Reports·Febin JohnC S Pitchumoni
Dec 16, 2016·Journal of the Royal Society, Interface·Casey BepplerPamela J Yeh
Feb 2, 2017·Journal of Strength and Conditioning Research·Brianna D McKayJoel T Cramer
Dec 2, 2017·CPT: Pharmacometrics & Systems Pharmacology·Pengyue ZhangLang Li
Feb 20, 2018·CPT: Pharmacometrics & Systems Pharmacology·Lang Li
Oct 9, 2018·IEEE Journal of Biomedical and Health Informatics·Danai ChasiotiLi Shen

❮ Previous
Next ❯

Citations

Mar 19, 2020·BMC Medical Informatics and Decision Making·Xia NingEwy Mathé
Feb 6, 2021·Journal of the American Medical Informatics Association : JAMIA·Matthew T PatrickLam C Tsoi
Feb 7, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yh Taguchi, Turki Turki

❮ Previous
Next ❯

Software Mentioned

OFFSIDES
R package “ arules ”

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

IEEE Journal of Biomedical and Health Informatics
Danai ChasiotiLi Shen
Ugeskrift for laeger
Lasse SaabyElsebeth Haunstrup
Journal of Young Pharmacists : JYP
Uv MatetiP Ramachandran
Trends in Pharmacological Sciences
Bethany Percha, Russ B Altman
© 2021 Meta ULC. All rights reserved