Mining association patterns of drug-interactions using post marketing FDA's spontaneous reporting data

Journal of Biomedical Informatics
Heba IbrahimA Sharaf Eldin

Abstract

Pharmacovigilance (PhV) is an important clinical activity with strong implications for population health and clinical research. The main goal of PhV is the timely detection of adverse drug events (ADEs) that are novel in their clinical nature, severity and/or frequency. Drug interactions (DI) pose an important problem in the development of new drugs and post marketing PhV that contribute to 6-30% of all unexpected ADEs. Therefore, the early detection of DI is vital. Spontaneous reporting systems (SRS) have served as the core data collection system for post marketing PhV since the 1960s. The main objective of our study was to particularly identify signals of DI from SRS. In addition, we are presenting an optimized tailored mining algorithm called "hybrid Apriori". The proposed algorithm is based on an optimized and modified association rule mining (ARM) approach. A hybrid Apriori algorithm has been applied to the SRS of the United States Food and Drug Administration's (U.S. FDA) adverse events reporting system (FAERS) in order to extract significant association patterns of drug interaction-adverse event (DIAE). We have assessed the resulting DIAEs qualitatively and quantitatively using two different triage features: a three-elem...Continue Reading

References

Jul 1, 1988·British Journal of Clinical Pharmacology·M D Rawlins
Jul 22, 1998·Journal of the American Medical Informatics Association : JAMIA·S E BrossetteS A Moser
Sep 24, 1999·SAR and QSAR in Environmental Research·N GreeneC A Marchant
Nov 10, 2000·Lancet·I R Edwards, J K Aronson
Jul 12, 2002·Statistics in Medicine·Peter G M van der HeijdenJacques W van der Hofstede
Jan 15, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L G Y Claeys, W Berg
Jun 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thorir D BjornssonUNKNOWN FDA Center for Drug Evaluation and Research (CDER)
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Donald W Aaronson
May 18, 2007·British Journal of Clinical Pharmacology·Bharat T ThakrarLucette Doessegger
Dec 1, 2007·Nucleic Acids Research·David S WishartMurtaza Hassanali
Dec 21, 2007·Leukemia·A PalumboUNKNOWN International Myeloma Working Group
Dec 26, 2007·Indian Journal of Ophthalmology·Rajul ParikhRavi Thomas
Feb 19, 2008·Cancer·Smitha Patiyil MenonAntonio Palumbo
Mar 18, 2008·Statistics in Medicine·G Niklas NorénI Ralph Edwards
Apr 16, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peter H BuiOliver Hankinson
Jun 27, 2008·Indian Journal of Ophthalmology·Younis Abed El-Wahhab Skaik
Oct 9, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Johan HopstadiusI Ralph Edwards
Aug 13, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Daniel Lalau
Apr 26, 2011·Journal of the American Medical Informatics Association : JAMIA·Stuart J NelsonRobin Moore
Jun 17, 2011·Journal of the American Medical Informatics Association : JAMIA·Nicholas P TatonettiRuss B Altman
Oct 26, 2013·Journal of the American Medical Informatics Association : JAMIA·Srinivasan V IyerNigam H Shah

❮ Previous
Next ❯

Citations

Feb 23, 2020·Healthcare Informatics Research·Selma Dere, Serkan Ayvaz
Jun 20, 2020·Therapeutic Innovation & Regulatory Science·Greg BallFrank W Rockhold
Jul 19, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sara HultG Niklas Norén
Nov 11, 2017·Knowledge and Information Systems·Sriraam NatarajanMichael Caldwell
Jun 23, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xing Jin, Ying Wu
Jun 12, 2020·Current Drug Safety·Oluwafemi Olawuyi, Kathleen Mathieson
Nov 16, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wanli KangShenjie Tang
Aug 4, 2017··Elke A. RundensteinerTabassum Kakar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.