Mining database for the therapeutic targets and prognostic biomarkers among STAT family in glioblastoma.

Cancer Biomarkers : Section a of Disease Markers
Chenglin LiYanyu Wu

Abstract

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor with a high mortality rate. Aberrant activation of signal transducers and activators of transcription (STAT) signaling results in tumor pathogenesis and progression by regulating cell cycle, cell survival and immune response. Therapeutic targets and prognostic biomarkers within the STAT family in GBM were explored using web applications and databases. High levels of STAT1/3/5A/5B/6 and low levels of STAT4 were observed in GBM patients. GBM patients expressing high STAT1/2/3/5A/6 and low STAT4/5B levels had the worse overall survival. Among the STAT family, STAT4 and STAT6 were the most frequently mutated genes. A low to moderate correlation among members of the STAT family was observed. Additionally, the STATs were involved in activation or inhibition of cancer related pathways. Analysis of immune infiltrates showed STAT5A levels to be significantly correlated with abundance of immune cells and levels of immune gene biomarkers. Gene ontology (GO) functions and KEGG pathway analysis indicated that STAT5A is involved in immune response-regulating signaling pathway, neutrophil and lymphocyte mediated immunity, single-stranded DNA binding, cytokine-c...Continue Reading

References

Aug 2, 2003·Oncogene·Ruty ShaiStanley F Nelson
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangMark A Israel
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 28, 2009·BMC Medical Genomics·Hideaki MizunoAkinori Sarai
Jan 17, 2015·Trends in Immunology·Diana Saleiro, Leonidas C Platanias
Mar 20, 2015·Phytotherapy Research : PTR·Niroshaathevi ArumuggamH P Vasantha Rupasinghe
Mar 8, 2016·Handbook of Clinical Neurology·Hans-Georg WirschingMichael Weller
Mar 26, 2016·Pathology, Research and Practice·Bruna R RodriguesVilma R Martins
May 25, 2016·Acta Biochimica Et Biophysica Sinica·Yuanzhong WuTiebang Kang
Oct 8, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zhaoqi YanEtty N Benveniste
Oct 21, 2016·Journal of Bone Oncology·Sofia Sousa, Jorma Määttä
Oct 21, 2016·Oncotarget·Uday B MaachaniAnita T Tandle
Jan 21, 2017·Nature Reviews. Endocrinology·David J ByunMonica Girotra
Feb 10, 2017·Annual Review of Immunology·Thomas A Waldmann, Jing Chen
Feb 28, 2017·Journal for Immunotherapy of Cancer·Patrick DanaherSteven P Fling
Jun 4, 2017·Molecular and Cellular Endocrinology·Bernd Groner, Viktoria von Manstein
Jun 10, 2017·Recent Patents on Anti-cancer Drug Discovery·Guojing LuoXijie Yu
Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian M Alexander, Timothy F Cloughesy
Aug 26, 2017·Asia-Pacific Journal of Clinical Oncology·Andrew Octavian SasmitaAnna Pick Kiong Ling
Nov 15, 2017·Nucleic Acids Research·Suhas V VasaikarBing Zhang
May 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yunsheng ZhangFusheng Liu
Jul 10, 2018·Nature Reviews. Neurology·Marike L BroekmanXandra O Breakefield
Oct 26, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Min LiHong-Bo Wang
Mar 7, 2019·Bioscience Reports·Fernando J VellosoRicardo G Correa
Oct 1, 2019·OncoTargets and Therapy·Zhitao DongYangqing Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.