Mining immune epitopes in the inner ear

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Michael PlattKonstantina M Stankovic

Abstract

Etiologies for many inner ear disorders, including autoimmune inner ear disease, sudden sensorineural hearing loss, and Meniere's disease, remain unknown. Indirect evidence suggests an immune-mediated process involving an allergic or autoimmune mechanism. We examined whether known immunogenic proteins share sequence similarity with inner ear proteins, which may lead to cross-reactivity and detrimental immune activation. Comprehensive bioinformatic analyses of primary sequences of intact and mutated proteins associated with human hearing loss and all proteins known to be expressed in the human inner ear were compared with all immune epitopes in the Immune Epitope Database. The exact match and basic local alignment search tool computational algorithms identified 3036 and 106 unique epitope matches, respectively, the majority of which were infectious epitopes. If validated in future clinical trials, these candidate immune epitopes in the inner ear would be potential novel targets for diagnosis and treatment of some inner ear disorders and the resulting hearing loss.

References

Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thankam S NairThomas E Carey
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moo-Jin BaekVincent K Tuohy
May 31, 2011·Otolaryngologic Clinics of North America·M Jennifer Derebery
Jul 12, 2011·Journal of Proteome Research·Andrew C LysaghtKonstantina M Stankovic

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Citations

Jan 23, 2016·Aging Cell·Shyan-Yuan KaoKonstantina M Stankovic
Oct 6, 2020·Frontiers in Neurology·Samuel EarlyKonstantina M Stankovic

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Methods Mentioned

BETA
protein folding
enzyme-linked immunosorbent assays

Software Mentioned

Python
BLAST

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