Mining on scorpion venom biodiversity

Toxicon : Official Journal of the International Society on Toxinology
Ricardo C Rodríguez de la VegaL D Possani

Abstract

Scorpion venoms are complex mixtures of dozens or even hundreds of distinct proteins, many of which are inter-genome active elements. Fifty years after the first scorpion toxin sequences were determined, chromatography-assisted purification followed by automated protein sequencing or gene cloning, on a case-by-case basis, accumulated nearly 250 amino acid sequences of scorpion venom components. A vast majority of the available sequences correspond to proteins adopting a common three-dimensional fold, whose ion channel modulating functions have been firmly established or could be confidently inferred. However, the actual molecular diversity contained in scorpion venoms -as revealed by bioassay-driven purification, some unexpected activities of "canonical" neurotoxins and even serendipitous discoveries- is much larger than those "canonical" toxin types. In the last few years mining into the molecular diversity contained in scorpion has been assisted by high-throughput Mass Spectrometry techniques and large-scale DNA sequencing, collectively accounting for the more than twofold increase in the number of known sequences of scorpion venom components (now reaching 500 unique sequences). This review, from a comparative perspective, de...Continue Reading

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Citations

Mar 1, 2014·Toxins·Zhijian CaoWenxin Li
Mar 19, 2014·Toxicon : Official Journal of the International Society on Toxinology·Bea G MilleJan Tytgat
Aug 26, 2014·Trends in Plant Science·Zebulun W ArendseeEve Syrkin Wurtele
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jennifer J SmithPaul F Alewood
Dec 30, 2015·Toxins·Carlos E Santibáñez-LópezLourival D Possani
Jul 16, 2014·Toxins·Sebastián Estrada-GómezLeidy Johana Vargas Muñoz
Jan 26, 2016·Toxins·Axel TouchardAlain Dejean
May 2, 2014·Journal of Proteomics·Xiaobo XuWenxin Li
Jan 17, 2012·Toxicon : Official Journal of the International Society on Toxinology·F CaliskanL D Possani
Feb 16, 2016·Biochemistry. Biokhimii︠a︡·A I KuzmenkovA A Vassilevski
Jul 19, 2015·Toxicon : Official Journal of the International Society on Toxinology·Carlos E Santibáñez-López, Lourival D Possani
Oct 20, 2015·Acta Tropica·Sebastián Estrada-GómezJuan Carlos Quintana Castillo
May 25, 2011·Toxicon : Official Journal of the International Society on Toxinology·B I García-GómezL D Possani
Feb 20, 2014·Toxicon : Official Journal of the International Society on Toxinology·Allen M CooperWilliam K Hayes
May 28, 2015·International Journal of Biological Macromolecules·Jing ChenYingliang Wu
Jul 16, 2013·Toxicon : Official Journal of the International Society on Toxinology·Fagner Neves OliveiraElisabeth F Schwartz
Mar 19, 2013·Toxicon : Official Journal of the International Society on Toxinology·Marie-France Martin-EauclairePierre E Bougis
Mar 20, 2013·Toxicon : Official Journal of the International Society on Toxinology·Emerson J VenancioDenise V Tambourgi
Nov 13, 2012·Toxicon : Official Journal of the International Society on Toxinology·Elia Diego-GarcíaFigen Caliskan
Nov 28, 2012·Toxicon : Official Journal of the International Society on Toxinology·Karen Luna-RamírezLourival D Possani
Oct 8, 2011·Toxicon : Official Journal of the International Society on Toxinology·V Quintero-HernándezL D Possani
Mar 31, 2015·Toxicon : Official Journal of the International Society on Toxinology·Bea G MilleJan Tytgat
Jul 21, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohamed A Abdel-RahmanPeter N Strong

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