Mining the granule proteome: a potential source of endocrine biomarkers

Biomarkers in Medicine
Jakob AlbrethsenAnders H Johnsen

Abstract

Proteomics of secretory granules is an emerging strategy for identifying secreted proteins, including potentially novel candidate biomarkers and peptide hormones. In addition, proteomics can provide information about the abundance, localization and structure (post-translational modification) of granule proteins and peptides. Analytical strategies within this research line include so-called 'subtractive proteomics', 'peptidomics' and granule purification by the use of multiple gradient centrifugations. Here we review the literature, and describe the challenges and opportunities in proteomics of secretory granules.

References

Mar 14, 2003·Nature·Ruedi Aebersold, Matthias Mann
May 6, 2003·Gastroenterology·David E Cummings, Karen E Foster
Jan 14, 2004·Molecular & Cellular Proteomics : MCP·N Leigh AndersonAnna Lobley
May 26, 2004·Biochimica Et Biophysica Acta·Elizabeth MuthGregory P Mueller
Jun 30, 2005·Molecular & Cellular Proteomics : MCP·George LominadzeKenneth R McLeish
Nov 10, 2005·Molecular & Cellular Proteomics : MCP·Xuequn ChenPhilip C Andrews
Apr 18, 2006·Cell·Leonard J FosterMatthias Mann
Sep 6, 2006·EMBO Reports·Jens S Andersen, Matthias Mann
Nov 15, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Masahiro HosakaTetsuro Izumi
Jun 23, 2007·Journal of Proteome Research·Michael J RindlerThomas A Neubert
Aug 29, 2007·Journal of Thrombosis and Haemostasis : JTH·D M MaynardW A Gahl
Dec 4, 2008·Journal of Proteomics·Sander R PiersmaConnie R Jiménez
Apr 22, 2010·Journal of Cellular and Molecular Medicine·Ilan HammelStephen J Galli
Aug 17, 2010·Journal of Proteome Research·Heike BortaMichael Schrader
Sep 2, 2010·Nature Methods·Tommy NilssonJohn J M Bergeron
Nov 26, 2010·Molecular & Cellular Proteomics : MCP·Gregory C LuermanKenneth R McLeish
Jul 27, 2011·Biochemistry·Arthur D Tinoco, Alan Saghatelian
Apr 4, 2012·Journal of Proteome Research·Dorothee van BreevoortJan Voorberg
May 10, 2012·Journal of Proteomics·Domitille SchvartzJean-Charles Sanchez
Dec 20, 2012·Molecular & Cellular Proteomics : MCP·Kazuki SasakiNaoto Minamino
Feb 12, 2014·Nature Reviews. Genetics·Shea J Andrews, Joseph A Rothnagel
Apr 15, 2014·Regulatory Peptides·Jens P Goetze, Jakob Albrethsen

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Citations

May 6, 2021·Metabolites·Nicholas NorrisMelkam Alamerew Kebede
Mar 21, 2018·Journal of the American Society for Mass Spectrometry·Christopher B LietzVivian Hook

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Methods Mentioned

BETA
proteomics profiling
electron microscopy
proteomic profiling

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