PMID: 7528354Aug 1, 1994Paper

Minireview: autoimmune responses to myelin proteolipid protein

Neurochemical Research
R A SobelV K Kuchroo

Abstract

The authors present a brief historical sketch of the development of our understanding of immune responses to myelin proteolipid protein (PLP) and the acceptance of PLP as a potent antigen in the induction of experimental allergic encephalomyelitis (EAE). The distinct characteristics of the PLP molecule that may contribute to complex immune responses to this protein are reviewed and these responses are compared with those to MBP, both in the pathology of EAE and at the level of the T cell. Recent evidence demonstrating differences between T cell responses to PLP and MBP is reviewed. Finally, the potential contribution of immune responses to PLP in human diseases, particularly multiple sclerosis (MS), that have been identified to date are then summarized.

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Citations

Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jane E LibbeyRobert S Fujinami
May 5, 1994·Regulatory Peptides·H OffnerA A Vandenbark
Feb 23, 2000·Journal of Neuroimmunology·D A SipkinsL Steinman
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Sep 7, 2006·The Journal of Clinical Investigation·Estelle BettelliVijay K Kuchroo
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Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·L B NicholsonV K Kuchroo
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Jun 1, 2016·Frontiers in Immunology·Soumya S Yandamuri, Thomas E Lane
Aug 21, 2009·Multiple Sclerosis : Clinical and Laboratory Research·M Podbielska, E L Hogan
Mar 3, 2004·Annals of Neurology·Leslie P WeinerMinnie McMillan

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