Minireview: prolactin regulation of adult stem cells

Molecular Endocrinology
Lucila Sackmann-SalaVincent Goffin

Abstract

Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including the mammary gland, the prostate, the brain, the bone marrow, the hair follicle, and colon cancer cells. Depending on the tissue, prolactin can either maintain stem cell quiescence or, in contrast, promote stem/progenitor cell expansion and push their progeny towards differentiation. In many instances, whether these effects are direct or involve paracrine regulators remains debated. This minireview aims to overview the current knowledge in the field.

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Citations

Apr 19, 2015·General and Comparative Endocrinology·Lucila Sackmann-SalaVincent Goffin
Oct 11, 2017·Journal of Molecular Histology·Flávia B ConstantinoLuis A Justulin
Jan 15, 2019·Endocrine-related Cancer·Vanessa M López-OzunaSuhad Ali
Dec 6, 2017·Reproduction, Fertility, and Development·Ana C L CamargoLuis A Justulin
Sep 19, 2020·Experimental Dermatology·Stefanie Heilmann-HeimbachMarkus M Nöthen
Mar 7, 2021·Biomolecules·Kimberly L P LongDaniela Kaufer
Jul 3, 2021·International Journal of Molecular Sciences·Maurycy JankowskiBartosz Kempisty

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