Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.

Molecular Endocrinology
Douglas Forrest, Anand Swaroop

Abstract

Rod and cone photoreceptors are specialized sensory cells that mediate vision. Transcriptional controls are critical for the development and long-term survival of photoreceptors; when these controls become ineffective, retinal dysfunction or degenerative disease may result. This review discusses the role of nuclear receptors, a class of ligand-regulated transcription factors, at key stages of photoreceptor life in the mammalian retina. Nuclear receptors with known ligands, such as retinoids or thyroid hormone, together with several orphan receptors without identified physiological ligands, complement other classes of transcription factors in directing the differentiation and functional maintenance of photoreceptors. The potential of nuclear receptors to respond to ligands introduces versatility into the control of photoreceptor development and function and may suggest new opportunities for treatments of photoreceptor disease.

References

Nov 15, 1979·The Journal of Comparative Neurology·L D Carter-Dawson, M M LaVail
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·R T YuK Umesono
Mar 9, 2000·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·A SzélP Röhlich
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·N B AkhmedovD B Farber
May 19, 2000·Cytokine & Growth Factor Reviews·P McCaffery, U C Dräger
Mar 17, 2001·Nature Reviews. Neuroscience·F J Livesey, C L Cepko
Nov 6, 2001·Nature Genetics·A J MearsA Swaroop
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ann H MilamSamuel G Jacobson
Sep 6, 2003·Nature Structural Biology·Catherine Stehlin-GaonRoland Schüle
Nov 20, 2003·Nature Neuroscience·Akihiro NishidaTakahisa Furukawa
Mar 24, 2004·Seminars in Cell & Developmental Biology·Jun Hatakeyama, Ryoichiro Kageyama
Jul 13, 2004·Trends in Cell Biology·Gérard BenoitThomas Perlmann
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takaya MiyawakiTeruyo Tanabe
Oct 2, 2004·Human Mutation·Alan F WrightAnand Swaroop
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jichao ChenJeremy Nathans
Jul 8, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brett S AbrahamsElizabeth M Simpson
Jul 27, 2005·Investigative Ophthalmology & Visual Science·Melanie R RobertsThomas A Reh
Jan 18, 2006·The Journal of Clinical Investigation·Arturo HernandezDonald St Germain
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Melanie R RobertsThomas A Reh
May 17, 2006·Genes & Development·Chun-Li ZhangRonald M Evans
Aug 2, 2006·Bioorganic & Medicinal Chemistry Letters·Scott E WolkenbergCraig W Lindsley
Oct 19, 2006·The Journal of Comparative Neurology·W Ted AllisonCraig W Hawryshyn
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Edwin C T OhAnand Swaroop
May 29, 2007·Drug Discovery Today·Yanhong Shi

❮ Previous
Next ❯

Citations

Feb 6, 2014·Cell and Tissue Research·Klaudia SzabóAkos Lukáts
Jul 31, 2013·Visual Neuroscience·David M Hunt, Leo Peichl
Jul 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Xiaoyong ZhiH Eric Xu
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Sep 13, 2016·Frontiers in Cellular Neuroscience·Yoshiyuki Henning, Karol Szafranski
Apr 4, 2014·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·A J Lawrance-OwenJ D Mollon
Oct 8, 2013·Journal of Molecular Endocrinology·Shannon E MullicanMitchell A Lazar
Apr 30, 2019·Endocrine Reviews·Antonio C BiancoBarbara M L C Bocco
May 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Korcan DemirTheo J Visser
Jul 28, 2016·Journal of Biomolecular Screening·Mayur Choudhary, Goldis Malek
Apr 8, 2017·Scientific Reports·A M OlivaresN B Haider
Apr 25, 2020·International Journal of Molecular Sciences·Pei-Li YaoGoldis Malek
Aug 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Robert D MackinDeborah L Stenkamp
Jul 5, 2018·Investigative Ophthalmology & Visual Science·Alexandra V GarafaloSamuel G Jacobson
Nov 24, 2015·Annual Review of Vision Science·Constance L Cepko
Sep 1, 2021·Scientific Reports·Yohey Ogawa, Joseph C Corbo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.