Minocycline- and tetracycline-class antibiotics are protective against partial seizures in vivo.

Epilepsy & Behavior : E&B
Doris D WangWilliam L Young

Abstract

Increasing evidence suggests the role of inflammation in enhancing neuronal excitability and contributing to epileptogenesis. Tetracycline-class antibiotics minocycline, doxycycline and tetracycline have been shown to have anti-apoptotic and anti-inflammatory effects. We investigated the anti-seizure effects of tetracycline-class antibiotics minocycline, doxycycline and tetracycline in vivo by using the maximal electric shock (MES), 6-Hz (minimal clonic seizure) test and subcutaneous Metrazol (scMET) models of epilepsy. Minocycline, doxycycline and tetracycline showed anticonvulsant effects in abolishing partial seizures in the mouse 6-Hz seizure test. A dose-dependent effect was found, with ED(50) of 170 mg/kg for minocycline, 157 mg/kg for doxycycline, and 255 mg/kg for tetracycline with peak onset at 0.5h. At high doses, minocycline (250 mg/kg) and doxycycline (150 mg/kg) also had toxic effects, from motor impairments to respiratory failure and death. These drugs had no effects on the MES and scMET tests. In the three tests of anti-seizure activity, minocycline, doxycycline, and tetracycline were found to be protective in one: the 6-Hz seizure model. Our data suggest that minocycline and other tetracycline-class drugs may of...Continue Reading

References

Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christine T EkdahlOlle Lindvall
Feb 25, 2006·Stroke; a Journal of Cerebral Circulation·Midori A YenariRona G Giffard
Mar 16, 2006·Current Opinion in Neurology·Nikolas Hitiris, Martin J Brodie
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Conrad C AlanoRaymond A Swanson
Aug 15, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R S RaoP Pandhi
Nov 4, 2008·Behavioural Brain Research·Hye-Sun Kim, Yoo-Hun Suh
Mar 9, 2011·Pharmacology, Biochemistry, and Behavior·Carlos Renato Alves NogueiraGlauce Socorro de Barros Viana
May 13, 2011·Epilepsia·Eleonora Aronica, Peter B Crino
Nov 8, 2011·Epilepsia·Annamaria VezzaniJacqueline French

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Citations

Dec 11, 2013·Translational Stroke Research·Robert M StarkeAaron S Dumont
Oct 15, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nooshin AhmadiradJavad Mirnajafi-Zadeh
Dec 17, 2014·Seminars in Pediatric Neurology·Joseph J Melvin, H Huntley Hardison
Oct 22, 2013·Epilepsy Research·Nicolas LangWalter Paulus
Sep 17, 2015·Journal of Neuroscience Methods·Katie LidsterMark J Prescott
Dec 19, 2015·European Journal of Pharmacology·Vera RussmannHeidrun Potschka
Oct 25, 2016·Journal of Traditional and Complementary Medicine·Vaishali YadavVikas Kumar
Jun 8, 2013·Seizure : the Journal of the British Epilepsy Association·Seyed Mehdi Beheshti NasrSeyed Mohammad Noorbakhsh
May 18, 2016·Glia·Ukpong B EyoLong-Jun Wu
Jan 31, 2017·Alcoholism, Clinical and Experimental Research·Alfredo Oliveros, Doo-Sup Choi
Sep 29, 2017·Expert Review of Clinical Pharmacology·Iyan Younus, Doodipala Samba Reddy
Mar 21, 2018·Canadian Journal of Physiology and Pharmacology·Hossein Amini-KhoeiAhmad Reza Dehpour
Sep 27, 2018·Expert Opinion on Emerging Drugs·Marco Mula
Apr 28, 2016·Nordic Journal of Psychiatry·Adam WysokińskiTomasz Kostka
Oct 10, 2014·The Australian and New Zealand Journal of Psychiatry·Lisa A HahnVera A Morgan
Jan 24, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bettina J WolfMarion Bankstahl
Jun 7, 2013·Expert Review of Neurotherapeutics·Raimondo D'AmbrosioEmilio Perucca
Jan 3, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anna-Maria SmolyakovaRobert B Laprairie
Dec 14, 2016·Journal of Neuroinflammation·Nina DupuisStéphane Auvin
Jul 20, 2019·CNS Drugs·Madison K Bangert, Rodrigo Hasbun
Nov 20, 2016·Alcoholism, Clinical and Experimental Research·Joseph M MartinezSusan E Bergeson
Feb 20, 2020·Mini Reviews in Medicinal Chemistry·Juan F MoralesAlan Talevi
Nov 19, 2020·Clinical EEG and Neuroscience·Luis A MartinezAnne E Anderson
Nov 4, 2020·Epilepsia·Manisha HolmesDeepak Saxena
Mar 6, 2021·Neurochemical Research·Tanveer Singh, Rajesh Kumar Goel
Mar 26, 2021·Seizure : the Journal of the British Epilepsy Association·Diana Marcela Mejía-GranadosPasquale Striano
Jun 3, 2021·International Journal of Molecular Sciences·Jana AmlerovaJakub Hort
Jun 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Viviane Bouilleret, Stefanie Dedeurwaerdere
Nov 10, 2021·Molecular Biology Reports·Shubham VishwakarmaThakur Gurjeet Singh

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