Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat

Behavioural Brain Research
Cai ZhangCai Song

Abstract

Activated microglia-induced neuroinflammation can stimulate the hypothalamic- pituitary-adrenal (HPA) axis to release glucocorticoids and suppress astrocyte functions, such as reducing neurotrophin production, which occur in depression. However, the balance between M1 (pro-inflammation) and M2 (anti-inflammation) microglial phenotypes and the interaction between these two glial cells are unclear in the depression. Hence, the chronic unpredictable mild stress (CUMS)-induced depression model was chosen to study depression- and anxiety-like behaviors, the concentration of corticosterone and relevant hippocampal cytokines, mRNA and protein expressions of microglial and astrocyte markers. To demonstrate the role of M1 phenotype activation in depression, the effect of microglial inhibitor minocycline on these aspects was also evaluated. Six weeks after CUMS exposure, behaviors were tested. Compared to the control group, CUMS increased serum corticosterone concentration and depression-like behaviors, like anhedonia, helplessness and anxiety. Moreover, CUMS increased microglia M1 marker CD11b expression and tumor necrosis factor (TNF)-α, interferon (INF)-γ, interleukin (IL)-1β and IL-17 concentrations, but decreased the concentration o...Continue Reading

Citations

Mar 7, 2020·Journal of Zhejiang University. Science. B·Er-Rong DuChang-Shui Xu
Nov 30, 2018·Genes, Brain, and Behavior·Marco R GuimarãesHugo Leite-Almeida
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Aug 1, 2020·Translational Psychiatry·Sinead RooneyNicolas Singewald
Feb 16, 2021·Neurochemistry International·Katherine PicardMarie-Ève Tremblay
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Girdhari Lal Gupta, Joneth Fernandes
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Jun 9, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Gabriele Cheiran PereiraGuilherme Vargas Bochi
Aug 19, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kinga JaworskaMarcin Ufnal
Apr 1, 2019·European Journal of Pharmacology·Huiling FuHanqing Wang

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