Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa

Molecular Pharmaceutics
Qingquan ChenCarolyn L Cannon

Abstract

Pseudomonas aeruginosa has been detected in the lungs of ∼50% of patients with cystic fibrosis (CF), including 20% of adult CF patients. The majority of these adult patients harbor multi-drug resistant (MDR) strains, limiting the available treatment options. Silver has long been used as a broad-spectrum antimicrobial agent with a low incidence of resistance. Despite low toxicity, poor availability of silver cations mandates a high dosage to effectively eradicate infections. To address this shortcoming of silver, nanoparticles have been used as delivery devices to improve treatment outcomes. Furthermore, studies have demonstrated that synergistic combinations with careful dose calibrations and efficient delivery systems result in superior antimicrobial activity while avoiding potential side effects of both therapeutics. Here 4-epi-minocycline, a metabolite of minocycline, was identified as an active antimicrobial against P. aeruginosa using a high-throughput screen. The antimicrobial activities of 4-epi-minocycline, minocycline, and silver acetate against clinical isolates of P. aeruginosa obtained from CF patients were evaluated in vitro. Next, the synergistic activity of the silver/minocycline combination against P. aeruginosa...Continue Reading

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Citations

Nov 25, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Davi de Lacerda CoriolanoIsabella Macário Ferro Cavalcanti
Nov 21, 2020·International Journal of Molecular Sciences·Minh Tam Tran ThiBernd H A Rehm
Dec 11, 2019·Journal of the American Chemical Society·Richen LiKaren L Wooley

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