Minocycline augmentation in older adults with persistent depression: an open label proof of concept study.

International Psychogeriatrics
Jimmy N AvariGeorge S Alexopoulos

Abstract

Less than 40% of depressed older adults treated with an antidepressant achieve remission. Incomplete response to treatment is common. Current augmentation strategies have limited efficacy, and many have side effects that restrict their utilization in older adults. We conducted the first open pilot trial of minocycline augmentation in older adults who had failed to achieve remission after adequate psychopharmacologic treatment. Subjects older than 55 years of age with major depression and failure to achieve substantial improvement of depressive symptoms after at least 6 weeks of antidepressant treatment were given augmentation with minocycline 100 mg twice daily over an 8-week period. At the end of 8 weeks of augmentation with minocycline, 31% (4/13) patients achieved remission. Remitters had higher baseline ratings of hopelessness and apathy. Minocycline was well tolerated with no reported adverse events or discontinuation due to intolerance. Larger placebo-controlled studies are needed to evaluate the effects of minocycline augmentation in older adults who had failed to achieve remission after adequate treatment with antidepressants.

References

Dec 3, 2008·Neuroimmunomodulation·Nathan L Sparkman, Rodney W Johnson
Mar 4, 2011·International Journal of Geriatric Psychiatry·George S Alexopoulos, Sarah Shizuko Morimoto
Mar 3, 2015·International Psychogeriatrics·Lisa S M EurelingsEric P Moll van Charante
Jul 16, 2015·Clinical and Experimental Pharmacology & Physiology·Kerui GongQing Lin
Dec 23, 2016·The EMBO Journal·Anna DariaSabina Tahirovic
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Mar 16, 2019·Drugs in Context·Seyda CankayaBurak Yulug
Aug 7, 2019·Translational Psychiatry·George S Alexopoulos

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