Minocycline differentially modulates viral infection and persistence in an experimental model of Japanese encephalitis.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Kallol DuttaAnirban Basu

Abstract

Japanese encephalitis (JE) is caused by a neurotropic flavivirus that causes CNS damage that leads to death in acute cases or permanent neuropsychiatric sequel in survivors. The course of infection of this virus is not well defined though it is clear that it evades the host's innate immune response in the periphery. The current study was designed to investigate the time-dependent changes in the spleen and lymph node, apart from the CNS that are infected by the Japanese encephalitis virus (JEV). Our previous studies have led to the identification of minocycline, a semi-synthetic antibiotic, as a protective drug in JE. In this study we have also investigated the role of minocycline on the peripheral organs that are infected by JEV. Levels of IL-12 and MCP-1 in the organs were estimated by cytometric bead array, and immunohistochemical studies were performed on cryosections of tissue to detect CD3- or CD11b-positive cells as well as JEV antigen. We found that the levels of T cell-activating cytokine IL-12 and MCP-1 levels were significantly elevated in JEV-infected tissue samples in a time-dependent manner. Corresponding to this increase was the increase in the number of CD3- and CD11b-positive cells in the tissues of infected ani...Continue Reading

References

Oct 1, 1991·The American Journal of Tropical Medicine and Hygiene·W C HallC J Peters
Feb 1, 1986·The Journal of General Virology·A MathurU C Chaturvedi
Mar 1, 1982·The Journal of General Virology·A MathurU C Chaturvedi
Jan 23, 1999·The American Journal of Pathology·P Van Der VoornC J De Groot
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J RoyD M Kranz
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nemuko OmataYusei Ohshima
May 20, 2003·Immunology and Cell Biology·Michael S Diamond
Aug 2, 2005·Nature Reviews. Immunology·Gwendalyn J RandolphMelody A Swartz
May 12, 2007·The Journal of Infectious Diseases·Jennifer L KyleEva Harris
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abi G AleyasSeong Kug Eo

❮ Previous
Next ❯

Citations

Mar 23, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Arshed NazmiAnirban Basu
Dec 21, 2012·Indian Pediatrics·Suvasini SharmaUNKNOWN Expert Group on Encephalitis, Indian Academy of Pediatrics
Jul 16, 2015·Basic & Clinical Pharmacology & Toxicology·Sandhya Nagarakanti, Eliahu Bishburg
Dec 15, 2015·Acta Neuropathologica·Martin LudlowAlbert D M E Osterhaus
Aug 25, 2012·Clinical & Developmental Immunology·Thananya ThongtanDuncan R Smith
Nov 13, 2012·Brain, Behavior, and Immunity·Sayantika MahantiBiswadev Bishayi
May 26, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hamid SalimiRobyn S Klein
Mar 31, 2017·F1000Research·Anirban Basu, Kallol Dutta
Aug 16, 2017·Journal of Neuroinflammation·Nils LannesLuis Filgueira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.