Minocycline enhances inhibitory transmission to substantia gelatinosa neurons of the rat spinal dorsal horn

Neuroscience
Huizhen PengT Liu

Abstract

Minocycline, a second-generation tetracycline, is well known for its antibiotic, anti-inflammatory, and antinociceptive effects. Modulation of synaptic transmission is one of the analgesic mechanisms of minocycline. Although it has been reported that minocycline may suppress excitatory glutamatergic synaptic transmission, it remains unclear whether it could affect inhibitory synaptic transmission, which also plays a key role in modulating pain signaling. To examine the effect of minocycline on synaptic transmission in rat spinal substantia gelatinosa (SG) neurons, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) using whole-cell patch-clamp recording at a holding potential of 0 mV. Bath application of minocycline significantly increased the frequency but not the amplitude of sIPSCs in a reversible and concentration-dependent manner with an EC50 of 85. The enhancement of inhibitory synaptic transmission produced by minocycline was not affected by the glutamate receptor antagonists CNQX and D-APV or by the voltage-gated sodium channel blocker tetrodotoxin (TTX). Moreover, the potency of minocycline for facilitating sIPSC frequency was the same in both glycinergic and GABAergic sIPSCs without changing their decay ...Continue Reading

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Oct 11, 2016·Scientific Reports·Maria Amalia Di CastroCristina Limatola
May 30, 2019·Journal of Neuroinflammation·Sergio M BorghiWaldiceu A Verri
Dec 21, 2019·Cephalalgia : an International Journal of Headache·Erika Ivanna ArayaJuliana Geremias Chichorro
Jun 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cheng-Yi YangKuei-Sen Hsu

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