Minocycline impairment of both osteoid tissue removal and osteoclastic resorption in a synchronized model of remodeling in the rat

Journal of Cellular Physiology
M Klapisz-Wolikow, J L Saffar

Abstract

In addition to their antibacterial effects, tetracyclines may inhibit interstitial collagenase activity and bone resorption. These properties were assessed morphometrically using minocycline (25 and 50 mg/kg/day given by the IM route) in a rat model of synchronized remodeling in which osteoclastic resorption peaks 4 days after the activating event (the extractions of the upper molars) along the antagonist mandibular cortex, a zone undergoing physiologically active formation. During the first 2 days of activation, minocycline at the two doses impaired very significantly the disorganization of both the osteoid seam and the layer of osteoblasts, a prerequisite to give osteoclasts access to the mineralized bone surface. The number of readily identifiable osteoblasts decreased slightly during this period, suggesting that minocycline prevented their transformation into lining cells. Their synthetic activity, as estimated by the size of the cells and their nucleus, appeared relatively preserved too, mostly with the higher dose. AT the peak of osteoclasia, the bone surfaces undergoing remodeling were significantly decreased in the minocycline-treated groups. The resorption surface was reduced (P < 0.0003) as well as the number of osteo...Continue Reading

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Citations

Jun 24, 2000·Bone·J T BettanyP S Grabowski
Jan 27, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SatoJ M Delaissé
Dec 14, 2011·Expert Opinion on Drug Safety·Rami KallalaEleftherios Tsiridis
Feb 28, 2013·British Journal of Pharmacology·N Garrido-MesaJ Gálvez
Mar 27, 2003·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Khin Ma Ma, Varawan Sae-Lim
Jan 9, 2004·The Journal of Bone and Joint Surgery. American Volume·Patrick E McCleskey, Kamala H Littleton
Jul 1, 2012·JBJS Case Connector·Charles M ChanBrian D Giordano

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