Minocycline in acne vulgaris: benefits and risks

American Journal of Clinical Dermatology
Falk Ochsendorf

Abstract

Minocycline is a semi-synthetic, second-generation tetracycline. It was introduced in 1972 and has both antibacterial and anti-inflammatory properties. Minocycline is used for a variety of infectious diseases and in acne. Even today, new indications beyond the antibacterial indications are being investigated such as its use in neurologic diseases. Formerly, minocycline was thought to have a superior efficacy in the treatment of inflammatory acne, especially with respect to antibacterial-resistant Propionibacterium acnes. A thorough review of the literature, however, shows that minocycline is not more effective in acne than other tetracyclines. Compared with first-generation tetracyclines, minocycline has a better pharmacokinetic profile, and compared with doxycycline it is not phototoxic. However, minocycline has an increased risk of severe adverse effects compared with other tetracyclines. It may induce hypersensitivity reactions affecting the liver, lung, kidneys, or multiple organs (Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS] syndrome) in the first weeks of treatment and, with long-term treatment, may cause autoimmune reactions (systemic lupus erythematosus, autoimmune hepatitis). In addition, CNS symptoms,...Continue Reading

References

Apr 1, 1977·Antimicrobial Agents and Chemotherapy·W L FanningR A Sofferman
May 1, 1975·Journal of Clinical Pathology·J D Oriel, P M Waterworth
May 1, 1992·Clinical and Experimental Dermatology·A M LaytonW J Cunliffe
Sep 15, 1992·Annals of Internal Medicine·J M GuillonC Mayaud
May 1, 1985·Archives of Dermatology·R S Basler
May 1, 1985·Archives of Dermatology·G GordonM J Iatropoulos
May 1, 1972·Archives of Dermatology·P FrostE C Gomez
Dec 1, 1982·Archives of Dermatology·C G HubbellJ W White
Jan 1, 1983·Journal of the American Academy of Dermatology·J J LeydenA M Kligman
Sep 1, 1993·Clinical and Experimental Dermatology·A M Layton, W J Cunliffe
Apr 1, 1996·The British Journal of Dermatology·V GouldenW J Cunliffe
Jun 1, 1996·Archives of Dermatological Research·P CélérierB Dréno
Oct 1, 1996·Archives of Dermatology·K A KnoellM Kutenplon
Feb 1, 1997·Journal of the American Academy of Dermatology·M MacNeilT J Marrie
Oct 24, 1997·Archives of Dermatology·L E ShapiroN H Shear
May 29, 1998·Lasers in Surgery and Medicine·B GreveC Raulin
Jun 25, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Eisen, M D Hakim
Jul 4, 1998·Lancet·S K Brown, A R Shalita
Mar 13, 1999·Archives of Internal Medicine·M C SturkenboomB H Stricker
Jul 16, 1999·Seminars in Arthritis and Rheumatism·O ElkayamD Caspi
Jun 1, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·R G SchliengerC R Meier
Aug 6, 2000·Archives of Family Medicine·E L Tanzi, M S Hecker
Oct 29, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R A LawrensonR D Farmer
Nov 4, 2000·Expert Opinion on Investigational Drugs·G S Alarcón
Feb 15, 2001·Journal of the American Academy of Dermatology·D Green, K J Friedman
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·I Chopra, M Roberts
Oct 5, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·B DrenoUNKNOWN Acne Research and Study Group
Nov 13, 2001·American Journal of Clinical Dermatology·E A Eady, J H Cove
Feb 28, 2002·Skin Pharmacology and Applied Skin Physiology·Claudine Piérard-FranchimontGérald E Piérard
Mar 19, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ilyse S FriedmanRobert G Phelps
Jul 26, 2002·Journal of the American Academy of Dermatology·Harold P LehmannSteven N Goodman
Dec 11, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Anthony Chapman-Davies, Anka Lazarevic
Mar 26, 2003·The British Journal of Dermatology·J I RossJ H Cove
Apr 23, 2003·Archives of Dermatology·Robert SkidmoreRobert Ashley
May 31, 2003·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·J BorgnonE Sapin
Jun 21, 2003·Journal of Periodontology·Lilibeth Ayangco, Phillip J Sheridan
Jan 16, 2004·Drugs·George G ZhanelDaryl J Hoban

❮ Previous
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Citations

Nov 28, 2013·Experimental Cell Research·Ansgar BrüningIoannis Mylonas
Aug 28, 2012·American Journal of Clinical Dermatology·Thierry Simonart
Sep 9, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Michael J Doughty
Nov 12, 2016·Frontiers in Oncology·Ajit Venniyoor, Bassim Al Bahrani
May 6, 2017·The American Journal of Dermatopathology·Angel Fernandez-FloresDavid S Cassarino
Mar 30, 2018·American Journal of Clinical Dermatology·Megha K TrivediLarissa N Larsen
Nov 7, 2018·Antimicrobial Agents and Chemotherapy·George ZhanelNancy Alvandi
Jan 31, 2012·The British Journal of Dermatology·B Lebrun-VignesUNKNOWN French Network of Regional Centers of Pharmacovigilance
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastUNKNOWN European Dermatology Forum
Apr 21, 2012·Cell Biochemistry and Function·İjlal ErturanVahide Baysal Akkaya
Apr 30, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Madhumitha RavikumarJeffrey R Capadona
Jun 20, 2020·Expert Review of Anti-infective Therapy·Harmanjit SinghPrerna Chauhan
Jul 4, 2020·The Annals of Pharmacotherapy·Erin St Onge, W Cary Mobley
Jan 20, 2015·The British Journal of Dermatology·C C Zouboulis, V Bettoli
Sep 15, 2020·Expert Opinion on Pharmacotherapy·Isabel Cristina Valente Duarte de Sousa
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Sarah E GarnerCatalin Mihai Popescu
Jul 20, 2016·Hospital Pediatrics·Madeleine W Schrier, Brian Alverson
Jul 6, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Klaus Degitz, Falk Ochsendorf
Jan 24, 2019·Scientific Reports·Daniel J ReisStephen S Ilardi
Feb 11, 2020·Expert Opinion on Pharmacotherapy·Isabel Cristina Valente Duarte de Sousa
Jul 6, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Klaus Degitz, Falk Ochsendorf
Sep 5, 2020·Clinical, Cosmetic and Investigational Dermatology·Angela Yen MooreAyman Grada
Dec 15, 2010·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Neil S SadickLior Laver
Jan 15, 2016·Pediatric Dermatology·Tuyet A Nguyen, Andrew C Krakowski

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