Minocycline-induced black bone disease encountered during total knee arthroplasty

Orthopedics
Dale N ReedR Scott Corpe

Abstract

Finding discolored bone intraoperatively can be confusing and concerning to orthopedic surgeons. Multiple causes of pigmented bone exist, including ochronosis, metabolic bone diseases, metal deposits, sequestrum, metastatic disease, and minocycline use. Bone quality is an important consideration in intraoperative decision making with respect to components and fixation options in total joint arthroplasty. Abnormal bone encountered in routine arthroplasty can raise concerns over the integrity and healing potential of the bone when the etiology is uncertain.Minocycline is a drug routinely used for the treatment of acne, rosacea, and rheumatoid arthritis. Pigmentation is a commonly recognized adverse reaction associated with most of the drugs in the tetracycline family, affecting the skin, nails, teeth, oral mucosa, bones in the oral cavity, ocular structures, cartilage, thyroid, and other visceral structures.This article describes a case of pigmented bone secondary to minocycline use in a 55-year-old woman undergoing total knee arthroplasty. This entity has rarely been documented in the orthopedic literature; however, orthopedic surgeons should be aware of this side effect secondary to the widespread use of minocycline. Questions ...Continue Reading

References

Apr 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·E W OdellR Haskell
Jun 25, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Eisen, M D Hakim
Feb 11, 1999·Advances in Dental Research·S WilliamsC T Liang
Nov 11, 1999·Current Opinion in Pediatrics·A H Eichenfield
Jan 9, 2004·The Journal of Bone and Joint Surgery. American Volume·Patrick E McCleskey, Kamala H Littleton
Oct 16, 2004·International Journal of Dermatology·Andrés R SánchezPhillip J Sheridan
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·S Pandit, W Hadden

❮ Previous
Next ❯

Citations

Feb 1, 2014·BMC Ophthalmology·Moritz Lindner, Thomas Bertelmann
Apr 30, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Madhumitha RavikumarJeffrey R Capadona
Jun 14, 2016·Case Reports in Orthopedics·Kazu MatsumotoHaruhiko Akiyama
Jul 2, 2014·Sports Health·Kristopher FayockJoshua Okon
Nov 7, 2019·Case Reports in Orthopedics·Wu Chean LeeYing Ho Chan
Aug 6, 2021·Journal of Orthopaedic Surgery and Research·William SteadmanChristopher J Wall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
S Sant'AmbrogioD DiMaio
The British Journal of Dermatology
M J HuntR Armati
Journal of Pediatric and Adolescent Gynecology
Soo Jung Kim, Joseph C English
© 2021 Meta ULC. All rights reserved