Minocycline-induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis

Journal of the European Academy of Dermatology and Venereology : JEADV
R P Dodiuk-GadS Brenner

Abstract

Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

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Citations

May 31, 2007·The Australasian Journal of Dermatology·Andrew J Birnie, Sheelagh M Littlewood
Jan 31, 2012·The British Journal of Dermatology·B Lebrun-VignesUNKNOWN French Network of Regional Centers of Pharmacovigilance
Feb 11, 2020·Expert Opinion on Pharmacotherapy·Isabel Cristina Valente Duarte de Sousa
Jul 10, 2018·Biomedical Optics Express·Sinyoung JeongConor L Evans

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