Minocycline-Induced Cutaneous Hyperpigmentation in an Orthopedic Patient Population

Open Forum Infectious Diseases
Yuri HanadaJames M Steckelberg

Abstract

Background.  The objectives of this study were to estimate the incidence and evaluate risk factors for development of minocycline-induced cutaneous hyperpigmentation in patients with orthopedic infections. Methods.  Patients with orthopedic infections evaluated at Mayo Clinic (Rochester, MN) and treated with minocycline from 1 January 2002 to 31 December 2011 were retrospectively identified. Long-term minocycline suppression was defined as daily minocycline use for at least 3 months. A proportional hazards model was used to evaluate potential risk factors. Results.  Of 291 patients receiving long-term minocycline suppression, 54% (156 of 291) developed hyperpigmentation after a mean follow-up of 4.8 years (range, 0.3-13.2 years); 88% involved blue-gray pigmentation of normal skin that appeared most commonly in the lower (75%) and upper extremities (44%). The mean duration of minocycline therapy before hyperpigmentation was 1.5 years (range, 0.1-9 years) with a mean cumulative dosage of 107.3 g (range, 8.6-657 g). Notable risk factors include a history of vitamin D deficiency (relative risk [RR], 6.29; 95% confidence interval [CI], 1.91-15.27; P = .0052), presence of a shoulder prosthesis (RR, 3.2; 95% CI, 1.23-6.56; P = .0062),...Continue Reading

References

Sep 5, 1980·JAMA : the Journal of the American Medical Association·N A FenskeK E Greer
Nov 1, 1980·Archives of Dermatology·J D McGrae, A S Zelickson
Aug 1, 1993·The British Journal of Dermatology·C M DwyerB F Allam
Apr 1, 1996·The British Journal of Dermatology·V GouldenW J Cunliffe
Oct 1, 1996·Archives of Dermatology·K A KnoellM Kutenplon
May 29, 1998·Lasers in Surgery and Medicine·B GreveC Raulin
Jan 20, 1999·Journal of Esthetic Dentistry·W H Bowles
Apr 12, 2003·American Journal of Clinical Dermatology·Hiok-Hee Tan
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
Jan 16, 2004·Clinical and Experimental Dermatology·R W MoutonJ W Schneider
Sep 10, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tina S Alster, Samir N Gupta
Jul 4, 2006·The Journal of Antimicrobial Chemotherapy·Kenneth N Agwuh, Alasdair MacGowan
Oct 18, 2007·Journal of the American Academy of Dermatology·Anneli Ririe Bowen, Timothy H McCalmont
Apr 24, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Brian T FayTed R Mikuls
Jan 29, 2010·Journal of Bone and Mineral Metabolism·Daniel D Bikle
Nov 3, 2010·Clinics in Dermatology·Mona ShahriariJane E Grant-Kels
Feb 22, 2012·International Journal of Dermatology·Arisa Ortiz, Sergei A Grando
Jun 12, 2013·Clinical, Cosmetic and Investigational Dermatology·Mahrukh S NisarAsad Ahmad

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Citations

Oct 19, 2016·Infection·Tetsuro Kobayashi, Kayoko Hayakawa
Jun 28, 2018·The Journal of the American Osteopathic Association·Leonid Skorin, Stephanie Norberg
May 25, 2021·Military Medicine·Yasmin F K Islam, Erich P Horn
Nov 10, 2021·JAMA : the Journal of the American Medical Association·Nina A RanMisha Rosenbach

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