Minocycline-induced DRESS: evidence for accumulation of the culprit drug

Dermatology : International Journal for Clinical and Investigative Dermatology
Eve MaubecJean-Claude Roujeau

Abstract

Minocycline-induced drug rash with eosinophilia and systemic symptoms (DRESS) may have a prolonged course, especially in African and African-American patients. To determine if a prolonged course of minocycline-induced DRESS was associated with an accumulation of the culprit drug. We determined plasma and skin levels of minocycline in patients with minocycline-induced DRESS. We investigated the genetic polymorphisms of enzymes potentially involved in the detoxification of the drug, glutathione S-transferases and UDP-glucuronosyltransferases. We demonstrated the persistence of minocycline in the plasma and/or in the skin of 7 out of 9 patients with skin phototypes V-VI. As pigmented skin contains more melanin, this could promote the formation of a melanin-minocycline complex, which could explain the severe and prolonged DRESS which may occur in this subgroup of patients.

References

Aug 1, 1989·The British Journal of Dermatology·N OkadaK Yoshikawa
Dec 1, 1988·Clinical Pharmacokinetics·S Saivin, G Houin
Jun 1, 1988·Archives of Dermatology·T B Fitzpatrick
Sep 1, 1980·Journal of the American Academy of Dermatology·J J Simons, A Morales
Aug 1, 1993·The British Journal of Dermatology·C M DwyerB F Allam
Apr 26, 1997·Lancet·N BénétonJ C Roujeau
Apr 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·W R WrightsonS Galandiuk
Apr 29, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·O ChosidowJ Revuz
Jun 25, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Eisen, M D Hakim
Sep 29, 2001·Pediatric Dermatology·J H Colvin, A P Sheth
Nov 19, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Collet DandaraJulia A Hasler

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Citations

Jul 31, 2009·Archives of Pharmacal Research·Srinivasan ShanmugamBong-Kyu Yoo
Jul 21, 2010·American Journal of Clinical Dermatology·Falk Ochsendorf
Mar 27, 2016·Dermatologic Clinics·Hyunhee Park, Stanley Skopit
Jul 3, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Vincent Descamps, Sylvie Ranger-Rogez
Jan 30, 2010·Annales de dermatologie et de vénéréologie·C MailholF Giordano-Labadie
Aug 12, 2009·Journal of the American Academy of Dermatology·Kerry K ShaughnessyKimberly S Salkey
Dec 23, 2008·La Revue de médecine interne·S ValadeA Kettaneh
Aug 27, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M MennickeW J Pichler
Jan 31, 2012·The British Journal of Dermatology·B Lebrun-VignesUNKNOWN French Network of Regional Centers of Pharmacovigilance
Dec 1, 2011·International Journal of Dermatology·Janelle R RickettsJane M Grant-Kels
Oct 22, 2016·Journal of Cutaneous Pathology·Phoebe StarKurosh Parsi
Aug 7, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Leslie A Hamilton, Anthony J Guarascio
Oct 8, 2020·European Journal of Clinical Pharmacology·Shiva SharifzadehSepideh Elyasi
Oct 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Ana Dioun BroylesMariana Castells

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