Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation.

Molecular Pain
Ik-Hyun ChoHyuk-Sang Jung

Abstract

Minocycline prevents the development of neuropathic and inflammatory pain by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates acute visceral pain is unclear. The present study investigated whether minocycline had an any antinociceptive effect on acetic acid-induced acute abdominal pain after intraperitoneal (i.p.) administration of saline or minocycline 1 hour before acetic acid injection (1.0%, 250 μl, i.p.). Minocycline (4, 10, or 40 mg/kg) significantly decreased acetic acid-induced nociception (0-60 minutes post-injection) and the enhancement in the number of c-Fos positive cells in the T5-L2 spinal cord induced by acetic acid injection. Also, the expression of spinal phosphorylated extracellular signal-regulated kinase (p-ERK) induced by acetic acid was reduced by minocycline pre-administration. Interestingly, intrathecal introduction of PD98059, an ERK upstream kinase inhibitor, markedly blocked the acetic acid-stimulated pain responses. These results demonstrate that minocycline effectively inhibits acetic acid-induced acute abdominal nociception via the inhibition of neuronal p-ERK expression in the spinal cord, and that minocycline may have therapeutic potential in suppressing a...Continue Reading

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Citations

Feb 4, 2014·European Journal of Pharmacology·Pradeep KannampalliJyoti N Sengupta
Nov 10, 2015·The Journal of Pain : Official Journal of the American Pain Society·Minhee JangIk-Hyun Cho
Feb 25, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gisela BorgesFani Neto
Jul 12, 2016·Biochemical and Biophysical Research Communications·Shilpa Lekshmi LeelaThawornchai Limjindaporn
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Sep 27, 2019·CNS Neuroscience & Therapeutics·Heng YangYu-Xiang Gu
May 14, 2021·Pain Reports·Conceição Elidianne Aníbal SilvaThiago Mattar Cunha

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