PMID: 8968031Dec 1, 1996Paper

Minocycline prevents the decrease in bone mineral density and trabecular bone in ovariectomized aged rats

Bone
S WilliamsC T Liang

Abstract

In the current study, we examined the effects of minocycline, on the osteopenia of ovariectomized aged rats. Old female rats were randomly divided into five groups: sham, ovariectomized control and ovariectomized treated with minocycline, 17beta-estradiol, or both agents. Bone samples were collected 8 wk after the treatment. Ovariectomy reduced bone mineral density of the whole femur and at the condylar, distal metaphyseal and head-neck-trochanter regions 10%-19% and the loss of bone density was prevented by treatment with minocycline or 17beta-estradiol. Histomorphometric analysis of distal femur showed ovariectomy reduced the trabecular bone area, the trabecular bone number, trabecular bone thickness and increased the trabecular bone separation. The microanatomic structure of trabecular bone also showed that the number of nodes, node to node, cortical to node, node to free end was reduced by ovariectomy. Treatment with minocycline attenuated the effect of ovariectomy on trabecular bone in aged animals. In contrast, cortical bone was not affected by ovariectomy or minocycline treatment. The effect of minocycline on bone turnover was also examined. Minocycline increased osteoid surface, mineralizing surface, mineral apposition ...Continue Reading

References

Sep 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Y TangD B Kimmel
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·L M GolubB R Rifkin
Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C C Liu, D N Kalu
Feb 1, 1990·Mechanisms of Ageing and Development·T TsujiA H Melcher
Jun 1, 1969·The Journal of Clinical Investigation·B L RiggsF T Maher
Feb 1, 1995·Calcified Tissue International·R QuartoC T Liang
Mar 27, 1993·Lancet·R Lindsay
Dec 1, 1993·Journal of Cellular Biochemistry·G R Mundy
Nov 1, 1996·Drug and Therapeutics Bulletin
May 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R W BoyceE F Eriksen
Dec 1, 1996·The Nurse Practitioner·M Scharbo-Dehaan

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Citations

Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M DelaisséN T Foged
Mar 15, 2011·Tissue Engineering. Part a·Balaji SitharamanJon P Longtin
Mar 19, 2014·PloS One·Claes OhlssonKlara Sjögren
Oct 17, 2012·Journal of Oral Microbiology·Ying GuLorne M Golub
Jan 1, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·M S WalterH J Haugen
Apr 8, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jianwen XuJie Song
Aug 25, 2007·Journal of Clinical Periodontology·Jeffrey B PayneLorne M Golub
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jeffry S NymanGregory R Mundy
Feb 28, 2013·British Journal of Pharmacology·N Garrido-MesaJ Gálvez
Dec 14, 2011·Expert Opinion on Drug Safety·Rami KallalaEleftherios Tsiridis
Dec 17, 2014·Trends in Endocrinology and Metabolism : TEM·Claes Ohlsson, Klara Sjögren
Oct 29, 2017·Calcified Tissue International·Claes Ohlsson, Klara Sjögren
Aug 30, 2017·Cold Spring Harbor Perspectives in Medicine·Roberto Pacifici
Oct 12, 2017·Calcified Tissue International·Emory Hsu, Roberto Pacifici
Jan 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saya KinugawaNobuyuki Udagawa
Jul 23, 1999·Annals of the New York Academy of Sciences·S WilliamsC T Liang
Jun 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christopher J HernandezSteven R Goldring
Apr 15, 2020·Current Osteoporosis Reports·René Rizzoli, Emmanuel Biver
Jun 20, 2017·Journal of the American College of Nutrition·Sadegh JafarnejadSeyed Ali Keshavarz
Jan 27, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A WakisakaC T Liang
Jul 1, 2012·JBJS Case Connector·Charles M ChanBrian D Giordano
Aug 23, 2019·International Journal of Molecular Sciences·Yeojin KimKyunghwan Kim
Sep 2, 2019·Colloids and Surfaces. B, Biointerfaces·Ning LiXiuyin Zhang
Oct 27, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brooks A SwansonChad M Novince

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