Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions

Molecular Neurobiology
Vinod KumarChetna Singh

Abstract

Accumulation of zinc (Zn) in dopaminergic neurons is implicated in Parkinson's disease (PD), and microglial activation plays a critical role in toxin-induced Parkinsonism. Oxidative stress is accused in Zn-induced dopaminergic neurodegeneration; however, its connection with microglial activation is still not known. This study was undertaken to elucidate the role and underlying mechanism of microglial activation in Zn-induced nigrostriatal dopaminergic neurodegeneration. Male Wistar rats were treated intraperitoneally with/without zinc sulphate (20 mg/kg) in the presence/absence of minocycline (30 mg/kg), a microglial activation inhibitor, for 2-12 weeks. While neurobehavioral and biochemical indexes of PD and number of dopaminergic neurons were reduced, the number of microglial cells was increased in the substantia nigra of the Zn-exposed animals. Similarly, Zn elevated lipid peroxidation (LPO) and activities of superoxide dismutase (SOD) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase; however, catalase activity was reduced. Besides, Zn increased an association of NADPH oxidase subunit p67(phox) with membrane, cytochrome c release from the mitochondria and cleavage of pro-caspase 3. Zn attenuated the expression...Continue Reading

References

Sep 28, 1999·Trends in Pharmacological Sciences·G W MillerM G Caron
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y DuS M Paul
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Du-Chu WuSerge Przedborski
May 22, 2003·Free Radical Biology & Medicine·Anya M Y LinC H J Yang
May 14, 2005·Antioxidants & Redox Signaling·Xue-Fei WuJau-Shyong Hong
Jun 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Hua HongAlex F Chen
Dec 15, 2006·Neurobiology of Disease·Maya G PurisaiDonato A Di Monte
Jun 27, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Anna L Bartels, Klaus L Leenders
Mar 26, 2008·Neurochemical Research·Rebecca L MillerAlbert Y Sun
Oct 7, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Fang ZhaoJingyuan Chen
Oct 23, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hironori YokoyamaTsutomu Araki
May 20, 2009·Antioxidants & Redox Signaling·Ana Clara CristóvãoYoon-Seong Kim
May 22, 2009·Journal of Neurochemistry·Hyman M SchipperDavid Zeligman
Jun 16, 2009·Biochemical and Biophysical Research Communications·Jing Chen-RoetlingRaymond F Regan
Mar 23, 2010·Cell·Christopher K GlassFred H Gage
May 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anand Kumar SinghMahendra Pratap Singh
Feb 16, 2012·Free Radical Biology & Medicine·Garima SrivastavaMahendra Pratap Singh
Dec 3, 2013·Journal of Neuroinflammation·Sachiko TanakaSatoshi Numazawa

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Citations

Jun 16, 2017·Neural Regeneration Research·Robert B Shultz, Yinghui Zhong
Nov 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Diego Romero-MiguelMaría Luisa Soto-Montenegro
May 6, 2021·International Journal of Molecular Sciences·Joanna Sikora, Abdel-Mouttalib Ouagazzal

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