Minocycline treatment prevents cavitation in rats after a cortical devascularizing lesion

Brain Research
Rui Hua, Wolfgang Walz

Abstract

Minocycline, a second-generation tetracycline, has been shown to possess neuroprotective effects in animal models of stroke. Pial vessel disruption in adult Wistar rats leads to a cone-shaped cortical lesion and turns into a fluid-filled cavity surrounded by a GFAP+ glia limitans 21 days after injury. This mimics the clinical situation in lacunar infarcts. Minocycline was given intraperitoneally at a dose of 45 mg/kg 1 and 12 h after lesioning, followed by 22.5 mg/kg twice daily until 6 days after lesioning. Control rats received intraperitoneal injections of equivalent volumes of saline. Cavitation was prevented in five out of six minocycline-treated animals and the glia limitans did not appear as the space was filled with GFAP+ reactive astrocytes. However, the number of activated microglia showed no difference between minocycline-treated and -untreated groups. Minocycline did not reduce the number of infiltrating leukocytes, predominately polymorphonuclear neutrophils (PMNs) determined by myeloperoxidase immunoreactivity, or infiltration of CD3+ lymphocytes. The pial vessel occlusion induced a significant upregulation of IL-1beta expression; however, minocycline treatment did not significantly alter this upregulation of IL-1...Continue Reading

References

Nov 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W J Streit
Aug 1, 1982·Neurology·C M Fisher
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J YrjänheikkiJ Koistinaho
Jan 8, 1999·Stroke; a Journal of Cerebral Circulation·K W Muir, D G Grosset
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J YrjänheikkiJ Koistinaho
Jun 9, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·T Boenisch
May 23, 2002·Brain : a Journal of Neurology·Veronika BrundulaV Wee Yong
Jul 12, 2002·Annals of Neurology·Kara L ArvinDavid M Holtzman
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna M PlanasAngel Chamorro
Jun 14, 2003·Brain : a Journal of Neurology·Jennifer E A WellsV Wee Yong
Aug 5, 2003·Journal of Neuroscience Research·Kai Wang, Wolfgang Walz
Sep 30, 2003·Journal of Neuroscience Research·Lichuan YangDavid S Albers
Dec 25, 2003·Cerebrovascular Diseases·Adrià Arboix, J L Martí-Vilalta
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yang D TengRobert M Friedlander
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David P StirlingWolfram Tetzlaff
Aug 7, 2004·Experimental Neurology·Masahiro TsujiMichael V Johnston
Nov 9, 2004·Trends in Pharmacological Sciences·María Domercq, Carlos Matute
Nov 24, 2004·Lancet Neurology·V Wee YongLuanne M Metz
Jan 28, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Milla KoistinahoJari Koistinaho
Mar 8, 2005·Journal of Neuroscience Research·Jeffrey E Gotts, Marie-Françoise Chesselet
Apr 23, 2005·Glia·Milos Pekny, Michael Nilsson
May 6, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christine FoxZinaida S Vexler

❮ Previous
Next ❯

Citations

Apr 6, 2007·Journal of Neural Engineering·R L RennakerD A Wilson
Aug 14, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Atticus H Hainsworth, Hugh S Markus
Oct 24, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G Miller Jonakait
Apr 25, 2009·Stroke; a Journal of Cerebral Circulation·Emma L BaileyJoanna M Wardlaw
Oct 27, 2007·Journal of Neuroscience Research·Rui HuaWolfgang Walz
Apr 23, 2013·Journal of Neuroscience Research·Francisco S CayabyabWolfgang Walz
Apr 19, 2017·Neurochemical Research·Wolfgang Walz, Francisco S Cayabyab

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes & Huntington’s Disease

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Astrocytes & Huntington’s Disease (MDS)

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.