Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis

European Journal of Pharmacology
Xiaohong ChenRongbiao Pi

Abstract

Previous evidence demonstrated that minocycline could ameliorate clinical severity of experimental autoimmune encephalomyelitis and exhibit several anti-inflammatory and neuroprotective activities. However, few studies have been carried out to assess its effects on the expression of neurotrophins in experimental autoimmune encephalomyelitis or multiple sclerosis. Here we investigated the alteration of brain-derived neurotrophic factor and nerve growth factor in the sera, cerebral cortex, and lumbar spinal cord of experimental autoimmune encephalomyelitis C57 BL/6 mice in vivo as well as the splenocytes culture supernatants in vitro after minocycline administration. Our results demonstrated that minocycline could up-regulate the expression of brain-derived neurotrophic factor and nerve growth factor both in peripheral (sera and splenocytes culture supernatants) and target organs (cerebral cortex and lumber spinal cord) of mice with experimental autoimmune encephalomyelitis. These data suggest that up-regulation of neurotrophins in experimental autoimmune encephalomyelitis may be a novel neuroprotective mechanism of minocycline.

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Citations

Aug 21, 2013·CNS Drugs·Amir-Hadi MaghziEmmanuelle Waubant
Jul 5, 2013·American Journal of Medical Genetics. Part a·Magdalena DziembowskaFlora Tassone
Apr 29, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ghassem Attarzadeh-YazdiAbbas Haghparast
Nov 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Diego Romero-MiguelMaría Luisa Soto-Montenegro

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