Minor alkaloids from Guatteria dumetorum with antileishmanial activity

Planta medica
Jhonny Edmith CorreaLuis Cubilla Rios

Abstract

Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine ( 3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1-4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.

Citations

May 6, 2010·Parasitology·E Holmes
Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Valery M DembitskyVladimir V Poroikov
Feb 20, 2015·Journal of Natural Products·Sudharshan Madapa, Wayne W Harding
Sep 26, 2014·Chemical Reviews·Hidayat HussainSimon Gibbons
Oct 6, 2016·Phytotherapy Research : PTR·Nazif UllahMuhammad Hamayun
Apr 12, 2013·Chemistry & Biodiversity·José Eraldo do N FontesDaniel P Bezerra
Sep 20, 2020·BMC Complementary Medicine and Therapies·Bobin MiJiayang Sai
Dec 25, 2016·Experimental Parasitology·C FerreiraE M Saraiva
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