Minor compounds from virgin olive oil attenuate LPS-induced inflammation via visfatin-related gene modulation on primary human monocytes

Journal of Food Biochemistry
Maria E MartinSergio Montserrat-de la Paz

Abstract

We have analyzed the effects of minor compounds found in the unsaponifiable fraction (UF) and in the phenolic fraction (PF) of virgin olive oil (VOO) on LPS-induced inflammatory response via visfatin modulation in human monocytes. For this purpose, monocytes were incubated with UF and PF at different concentrations and the pro-inflammatory stimulus LPS for 24 hr; squalene (SQ) and hydroxytyrosol (HTyr), the main components in UF and PF, respectively, were also used. The relative expression of both pro-inflammatory and anti-inflammatory genes, as well as other genes related to the NAD+-biosynthetic pathway was evaluated by RT-qPCR; and the secretion of some of these markers was assessed by ELISA procedures. We found that UF, SQ, PF, and HTyr prevented from LPS-induced dysfunctional gene expression and secretion via visfatin-related gene modulation in human monocytes. These findings unveil a potential beneficial role for minor compounds of VOO in the prevention of inflammatory-disorders. PRACTICAL APPLICATION: In this project, potential health benefits of VOO micronutrients (unsaponifiable and phenolic compounds) were confirmed through anti-inflammatory assays. Our results reveal new interesting researching goals concerning nutri...Continue Reading

References

May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Apr 3, 2012·Annual Review of Nutrition·Tuva B DahlBente Halvorsen
Jun 13, 2012·The Journal of Biological Chemistry·Franziska BuschMehdi Shakibaei
Dec 15, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S Sánchez-FidalgoC Alarcón de la Lastra
Jan 23, 2013·The Journal of Nutritional Biochemistry·Susana Sánchez-FidalgoCatalina Alarcón de la Lastra
Mar 13, 2013·The Journal of Nutritional Biochemistry·Patrizia RosignoliGuido Morozzi
Jul 10, 2013·Current Medicinal Chemistry·A CárdenoC Alarcón-de-la-Lastra
Nov 30, 2013·Biochimica Et Biophysica Acta·Alberto Benito-MartinAlberto Ortiz
Jan 21, 2014·Biochimica Et Biophysica Acta·Sergio LopezFrancisco J G Muriana
Feb 1, 2014·Arthritis Research & Therapy·Marie-Charlotte LaiguillonJérémie Sellam
Mar 5, 2016·Journal of the American College of Cardiology·Peter LibbyFilip K Swirski
Jun 25, 2016·Molecular Nutrition & Food Research·M Carmen NaranjoSergio Montserrat-de la Paz
Aug 23, 2016·Annals of Clinical and Translational Neurology·Erik S MusiekDavid M Holtzman
Oct 25, 2016·The Journal of Nutritional Biochemistry·Sergio Montserrat-de la PazBeatriz Bermudez
Oct 27, 2016·Food & Function·Marina Aparicio-SotoCatalina Alarcón-de-la-Lastra
Nov 26, 2016·Food & Function·Sergio Montserrat-de la PazFrancisco J G Muriana
Dec 23, 2016·Innate Immunity·Yanhui JiaDahai Hu
Dec 28, 2016·Neurochemistry International·Alireza VakilianGholamhossein Hassanshahi
Feb 22, 2017·Molecular Nutrition & Food Research·Sergio Montserrat-de la PazSergio Lopez
Apr 15, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Beatriz BermudezErik Anna Leonardus Biessen

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.