Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng

Fitoterapia
Cheng-Zhen GuYing-Jun Zhang

Abstract

Nine new minor dehydrogenated and cleavaged dammarane-type triterpenoid saponins, namely notoginsenosides ST6-ST14 (1-9) were isolated from the steamed roots of Panax notoginseng, together with 14 known ones. Among them, 5-7 and 21-22 were protopanaxadiol type and the left 18 compounds, including 1-4, 8-20, and 23 were protopanaxatriol type saponins. Their structures were identified by extensive analysis of MS, 1D and 2D NMR spectra, and acidic hydrolysis. Resulted from the side chain cleavage, the new saponins 1 and 2 featured in a ketone group at C-25, and 3-5 had an aldehyde unit at C-23. The known saponins 12, 16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μM, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 μM.

References

Sep 7, 2002·Archives of Pharmacal Research·Il Ho ParkJeong Hill Park
Sep 1, 2004·Circulation·Shiladitya SenguptaTai-Ping D Fan
Dec 8, 2005·International Immunopharmacology·Hongxiang SunYiping Ye
Jul 17, 2007·Journal of Natural Products·Guangtong ChenDe-an Guo
Nov 28, 2007·Applied Microbiology and Biotechnology·Guang-Tong ChenDe-An Guo
Feb 8, 2008·Journal of Agricultural and Food Chemistry·Peng-Ying LiaoChong-Ren Yang
Aug 6, 2010·Chemical & Pharmaceutical Bulletin·Nguyen Huu TungYoung Ho Kim
Feb 1, 2011·Journal of Asian Natural Products Research·Shi-Jin QuDa-Yuan Zhu
May 31, 2011·Journal of Asian Natural Products Research·Ying PeiYing-Jun Zhang
Apr 30, 2013·Journal of Natural Products·Jun-Jiang LvYing-Jun Zhang
Feb 22, 2014·Journal of Agricultural and Food Chemistry·Jing-Rong WangZhi-Hong Jiang

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Citations

Aug 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingya RuanTao Wang
Apr 1, 2017·Natural Product Research·Zong WanGui-Guang Cheng
Aug 2, 2017·Natural Product Research·Cheng-Zhen GuYing-Jun Zhang
Feb 15, 2020·Natural Product Reports·Robert A Hill, Joseph D Connolly
Jul 8, 2018·Natural Products and Bioprospecting·Yi-Jun QiaoYing-Jun Zhang
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huiying LiuYuan Qu
Oct 9, 2020·Journal of Asian Natural Products Research·Chong-Kang YangYong Shen

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