Minor head trauma-induced sporadic hemiplegic migraine coma

Pediatric Neurology
Robert P CurtainLyn R Griffiths

Abstract

Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene (chromosome 19p13) for familial hemiplegic migraine. Recently a gene mutation (Serine-218-Leucine) for a dramatic syndrome associated with familial hemiplegic migraine, commonly named "migraine coma", has implicated exon 5 of this gene. The occurrence of trivial head trauma, in such familial hemiplegic migraine patients, may also be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval. Sporadic hemiplegic migraine shares a similar spectrum of clinical presentation and genetic heterogeneity. The case report presented in this article implicates the involvement of the Serine-218-Leucine mutation in the extremely rare disorder of minor head trauma-induced migraine coma. We conclude that the Serine-218-Leucine mutation in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene is involved in sporadic hemiplegic migraine, delayed cerebral edema and coma after minor head trauma.

Citations

Mar 31, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniela Pietrobon
Mar 26, 2009·Journal of Paediatrics and Child Health·Anthony R HartSantosh R Mordekar
Feb 18, 2009·Cephalalgia : an International Journal of Headache·M-J CastroA M J M van den Maagdenberg
May 15, 2009·Cephalalgia : an International Journal of Headache·S DebiaisA Autret
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katharina Eikermann-HaerterCenk Ayata
May 21, 2009·Human Genetics·Boukje de VriesArn M J M van den Maagdenberg
Apr 12, 2014·Cell and Tissue Research·Ortrud K Steinlein
Jan 28, 2016·Developmental Medicine and Child Neurology·Esther M TantsisManoj P Menezes
Aug 23, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·E Daniëlle van PeltCoriene E Catsman-Berrevoets
Aug 10, 2011·Pediatric Neurology·Sawako YamazakiYoshiki Adachi
Jul 23, 2008·Journal of the Neurological Sciences·Andrea GallantiMaria Teresa Bassi
May 19, 2007·Lancet Neurology·Maija WessmanRoel A Ophoff
Apr 11, 2008·Clinical Genetics·A H StamG M Terwindt
Aug 28, 2007·Developmental Medicine and Child Neurology·Z ZolkipliB G R Neville
Feb 6, 2014·Molecular Genetics & Genomic Medicine·Oriel CarreñoBru Cormand
Oct 9, 2009·Developmental Medicine and Child Neurology·Timothy J MalpasBrian G R Neville
Feb 27, 2010·Annals of Neurology·Arn M J M van den MaagdenbergMichel D Ferrari
Oct 7, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Angelina R A PikstraJoukje van der Naalt
Jan 7, 2017·Cephalalgia : an International Journal of Headache·P PronteraC Costa
Sep 18, 2016·Neurosurgery Clinics of North America·Joshua Kamins, Christopher C Giza
Jan 26, 2010·Journal of Child Neurology·Lubov BlumkinTally Lerman-Sagie
Sep 22, 2016·Cephalalgia : an International Journal of Headache·Francesca CamiaMaria Margherita Mancardi
Aug 1, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E IndelicatoS Boesch
Sep 18, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Manisha R ChandEvan Peck
May 15, 2007·Current Opinion in Neurology·Arn M J M van den MaagdenbergMichel D Ferrari
Mar 17, 2019·Military Medicine·Brian A MooreAlan L Peterson
Mar 2, 2010·Expert Review of Neurotherapeutics·Michael Bjørn Russell
Aug 3, 2013·Reviews in the Neurosciences·Katharina Eikermann-HaerterCenk Ayata
Apr 3, 2020·Journal of Neurotrauma·Omar IbrahimLyn R Griffiths

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