Jan 1, 1977

Minor influence of parathyroid hormone on fractional tubular reabsorption of phosphate in chronic renal failure

Advances in Experimental Medicine and Biology
M S ChristensenP Rodbro


In untreated patients with chronic renal failure and glomerular filtration rates (GFR) between 10 and 25 ml/min the decrease in fractional tubular reabsorption of phosphate was correlated to the degree of secondary hyperparathyroidism. This correlation was not found in patients with GFR below 10 ml/min. During treatment with 1alpha-hydroxycholecalciferol for 11 weeks: a) serum parathyroid hormone concentration decreased in all patients on average 60%, and was normal in 5 patients after treatment b) fractional tubular reabsorption of phosphate decreased significantly (on average 0.21) c) glomerular filtration rate decreased significantly (on average 27.5%). Since the reduction (or normalization) of serum parathyroid hormone concentration did not increase the fractional tubular reabsorption of phosphate, other (GFR-related) factors than parathyroid hormone play the major role for renal handling of phosphate in chronic renal failure when GFR is below 25 ml/min.

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Mentioned in this Paper

Parathyroid Hormone Peptide (1-34)
PTH protein, human
Hyperparathyroidism, Secondary
Recombinant parathyroid hormone
Renal Tubule Structure
Parathyroid Hormone [EPC]
Phosphate Measurement
PTH gene

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